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MRA/fMRI Study of Spontaneous Migraine

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01471314
Recruitment Status : Unknown
Verified August 2012 by Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen.
Recruitment status was:  Recruiting
First Posted : November 15, 2011
Last Update Posted : August 29, 2012
Leiden University Medical Center
Information provided by (Responsible Party):
Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen

Brief Summary:

The purpose of this study is to examine migraineurs during spontaneous migraine attacks without aura, using high resolution magnetic resonance imaging (MRI), to study following:

  • Changes in resting state blood-oxygenation-level-dependent-signal (BOLD-signal) using functional MRI (fMRI).
  • Changes in circumferences of intra- and extracranial arteries using MR-angiography (MRA).
  • Changes in regional and global cerebral blood flow (CBF) using the arterial spin labeling (ASL) method.

Moreover to perform diffusion tensor imaging (DTI) scans during spontaneous migraine attacks.

The migraine specific drug sumatriptan will be given to relieve pain and the effect will be registered using MRA and fMRI if possible.

Condition or disease Intervention/treatment
Headache Versus Non-headache Day Behavioral: Headache day versus non-headache day

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Study Type : Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Functional MRI and MR Angiography Used in Spontaneous Migraine

Resource links provided by the National Library of Medicine

MedlinePlus Genetics related topics: Migraine
MedlinePlus related topics: Headache Migraine

Group/Cohort Intervention/treatment
Spontaneous migraine Behavioral: Headache day versus non-headache day

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Migraine without aura

Inclusion Criteria:

  • Migraine without aura according to IHS criteria.

Exclusion Criteria:

  • Other primary headaches.
  • Tension-type headache more than 5 days/month.
  • Use of anti-pain medication before the scanning on the examination day.
  • Pregnant or nursing women.
  • Contraindication for MR scan.
  • Anamnestic or clinical signs of cardiovascular or cerebrovascular disease, unregulated psychiatric disease or drug misuse.
  • Other clinical conditions assessed by the examining doctor.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01471314

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Contact: Faisal Amin, MD, PhD student +4538633066

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Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen Recruiting
Glostrup, Denmark, DK-2600
Contact: Faisal Amin, MD, PhD student    +4538633066   
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
Leiden University Medical Center
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Faisal Mohammad Amin, MD, PhD student, Glostrup University Hospital, Copenhagen Identifier: NCT01471314    
Other Study ID Numbers: H-C-2008-089
First Posted: November 15, 2011    Key Record Dates
Last Update Posted: August 29, 2012
Last Verified: August 2012
Additional relevant MeSH terms:
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Neurologic Manifestations