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Relation of Glucose and Acute Pancreatitis (ROGAAP)

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ClinicalTrials.gov Identifier: NCT01470885
Recruitment Status : Completed
First Posted : November 11, 2011
Last Update Posted : May 5, 2014
Sponsor:
Collaborator:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Information provided by (Responsible Party):
xiaolong zhao, Huashan Hospital

Brief Summary:
Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Part of endocrine function of pancreas would be affected in AP. Stress hyperglycemia would explode at acute phase. So the investigators decide to follow up and observe 200 cases of patients with acute pancreatitis, determining of blood sugar, blood amylase, hemoglobin and glycosylated hemoglobin level. At last, using ROC curve method to identify the die cutting between blood glucose level and acute pancreatitis, and makes analysis of the diagnostic value.

Condition or disease
Acute Pancreatitis

Detailed Description:
Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Part of endocrine function of pancreas would be affected in AP. Stress hyperglycemia would explode at acute phase. There are two reasons. One is because that sympathetic hyperactivity makes glucagon elevated. Secondary, microcirculation disorder makes pancreas edema, ischemia and necrosis, affecting secretion and excretion of insulin. In severe acute pancreatitis, there may be ketoacidosis. Many scoring systems for predicting prognosis of severe acute pancreatitis also contains glucose values, such as the Ranson scoring system and the Glascow scoring system. On the other hand, Type 2 diabetes has become a global pandemic disease. Most of patients of type 2 diabetes are obese, who easily complicated gallstone disease and hypertriglyceridemia. All of above could be the risk factors for acute pancreatitis. Our initial small sample research also suggests undiagnosed diabetes patients whose glucose value elevated is significantly worse than the known diabetic patients. Therefore, the investigators believe that glucose directly affects the prognosis of AP. So the investigators decide to follow up and observe 1000 cases of patients with acute pancreatitis, determining of blood sugar, blood amylase, hemoglobin and glycosylated hemoglobin level. At last, using ROC curve method to identify the die cutting between blood glucose level and acute pancreatitis, and makes analysis of the diagnostic value.

Study Type : Observational
Actual Enrollment : 350 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: the Influence of Glucose to the Prognosis of Patients of Acute Pancreatitis
Study Start Date : March 2011
Actual Primary Completion Date : December 2011
Actual Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pancreatitis
Drug Information available for: Dextrose
U.S. FDA Resources

Group/Cohort
glucose value
glucose value



Primary Outcome Measures :
  1. motability [ Time Frame: motability ]
    motability after acute pancreatitis



Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years to 85 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
primary care clinic
Criteria

Inclusion Criteria:

patients that newly diagnosed as acute pancreatitis.

Exclusion Criteria:

exclude other acute abdomen, such as peptic ulcer with perforation, mesenteric arterial embolism or ruptured ectopic pregnancy.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01470885


Locations
China, Shanghai
Xiaolong Zhao
Shanghai, Shanghai, China, 21012
Sponsors and Collaborators
Huashan Hospital
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Publications of Results:
Responsible Party: xiaolong zhao, endocrinology department, Huashan Hospital
ClinicalTrials.gov Identifier: NCT01470885     History of Changes
Other Study ID Numbers: zsdxxhnk20110707
First Posted: November 11, 2011    Key Record Dates
Last Update Posted: May 5, 2014
Last Verified: May 2014

Keywords provided by xiaolong zhao, Huashan Hospital:
glucose
prognosis
glycated hemoglobin

Additional relevant MeSH terms:
Pancreatitis
Pancreatic Diseases
Digestive System Diseases