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Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength, Pain and Mobilization After Total Knee Replacement

This study has been completed.
Information provided by (Responsible Party):
Pia Jaeger, Rigshospitalet, Denmark Identifier:
First received: November 9, 2011
Last updated: December 17, 2012
Last verified: December 2012

The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the Femoral Nerve Block on muscle strength, pain and mobilization after total knee arthroplasty. We hypothesize that the Adductor-Canal-Blockade has the same effect on pain and morphine consumption as the Femoral Nerve Block, but without the same reduction in quadriceps muscle strength.

Condition Intervention
Total Knee Arthroplasty
Procedure: Adductor-Canal-Blockade
Procedure: Femoral Nerve Block

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: "A Comparison of the Efficacy of the Adductor-Canal-Blockade Versus the Femoral Nerve Block on Muscle Strength, Pain and Mobilization After Total Knee Arthroplasty: a Randomized Study

Resource links provided by NLM:

Further study details as provided by Rigshospitalet, Denmark:

Primary Outcome Measures:
  • The difference in quadriceps muscle strength between the Adductor-Canal-Blockade and the femoral nerve block [ Time Frame: 24 h postoperatively ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • The difference in adductor muscle strength between the Adductor-Canal-Blockade and the Femoral Nerve Block [ Time Frame: 24 h postoperatively ] [ Designated as safety issue: No ]
  • Pain during flexion of the knee [ Time Frame: 2-24 hours ] [ Designated as safety issue: No ]
    0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.

  • Pain at rest [ Time Frame: 2-24 hours ] [ Designated as safety issue: No ]
    0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.

  • Total morphine consumption [ Time Frame: 0-24 hours ] [ Designated as safety issue: No ]
  • Postoperative nausea [ Time Frame: 2-24 hours ] [ Designated as safety issue: No ]
  • Postoperative vomiting [ Time Frame: 0-24 hours ] [ Designated as safety issue: No ]
  • Sedation [ Time Frame: 2-24 hours ] [ Designated as safety issue: No ]
  • Zofran consumption [ Time Frame: 0-24 hours ] [ Designated as safety issue: No ]
    Number of patients recieveing zofran postoperatively

  • The difference in mobilization between the groups [ Time Frame: 24 hours ] [ Designated as safety issue: No ]

Enrollment: 54
Study Start Date: November 2011
Study Completion Date: November 2012
Primary Completion Date: November 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Adductor-Canal-Blockade Procedure: Adductor-Canal-Blockade
US-guided Adductor-Canal-Blockade with Ropivacaine
Active Comparator: Femoral Nerve Block Procedure: Femoral Nerve Block
US-guided Femoral Nerve Block with Ropivacaine


Ages Eligible for Study:   50 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ASA 1-3
  • BMI > 18 og < 40
  • total knee arthroplasty in spinal anesthesia

Exclusion Criteria:

  • Can not cooperate to the exam
  • Do not speak or understand Danish
  • Drug allergy
  • Alcohol or drug abuse
  • Daily consumption of strong opioids
  • Rheumatoid arthritis
  • Intake of glucocorticoids
  • Effect of spinal anesthesia stopped prior to performing the regional block
  Contacts and Locations
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Please refer to this study by its identifier: NCT01470391

Department of Anaesthesia, Copenhagen University Hospital, Frederiksberg
Frederiksberg, Denmark, 2000
Sponsors and Collaborators
Rigshospitalet, Denmark
Principal Investigator: Pia Jæger, MD Rigshospitalet, Denmark
  More Information

No publications provided by Rigshospitalet, Denmark

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Pia Jaeger, MD, Rigshospitalet, Denmark Identifier: NCT01470391     History of Changes
Other Study ID Numbers: SM1-PJ-11
Study First Received: November 9, 2011
Last Updated: December 17, 2012
Health Authority: Denmark: The Regional Committee on Biomedical Research Ethics
Denmark: Danish Dataprotection Agency

Keywords provided by Rigshospitalet, Denmark:
Femoral Nerve Block
Postoperative Pain
Total Knee Arthroplasty processed this record on February 26, 2015