Hypodontia and Ovarian Cancer
Recruitment status was: Recruiting
The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones).
If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.
|Study Design:||Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:||Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer.|
- Prevalence rates of hypodontia in women with ovarian cancer [ Time Frame: one year ] [ Designated as safety issue: No ]
- Genetic causes for hypodontia and ovarian cancer [ Time Frame: two years ] [ Designated as safety issue: No ]
- Prevalence rates of hypodontia in patients with a known risk for epithelial cancer [ Time Frame: one year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
5ml EDTA full blood for DNA analysis.
1 PAX-tube for RNA analysis. Biopsi from removed tumor-tissue for DNA analysis. Both preserved in Danish Cancer Biobank for later analysis.
|Study Start Date:||September 2011|
|Estimated Study Completion Date:||August 2015|
|Estimated Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
Women treated for ovarian cancer at the departments of obstetrics and gynecology, Aarhus University Hospital and Rigshospitalet, Copenhagen.
Expected recruitment: 200
Women referred to the departments of obstetrics and gynecology in Aarhus University Hospital and Rigshospitalet, Copenhagen on benign indication.
Expected recruitment: 200.
Patients registered in the large Danish Register of HBOC( hereditary breast and ovarian cancer) and HNPCC (hereditary nonpolyposis colorectal cancer).
Expected recruitment: 200.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01470235
|Aarhus University Hospital|
|Skejby, Aarhus, Denmark, 8000|
|Copenhagen University Hospital|
|Copenhagen Ø, Copenhagen, Denmark, 2100|
|Study Director:||Jan Blaakaer, Professor, MD, DMSc||Aarhus University Hospital|
|Principal Investigator:||Maria Cathrine C. V. Schmidt, MD, Ph.d.-student||Aarhus University Hospital|
|Study Chair:||Charlotte Soegaard, MD, ph.d.||Aarhus University Hospital|
|Study Chair:||Lone Sunde, Associate Professor, PhD||Aarhus University Hospital|
|Study Chair:||Claus Hoegdall, Professor||Copenhagen University Hospital|
|Study Chair:||Michala O. Lexner, Dentist, PhD|