Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Platelet Inhibition and Bleeding in Patients Undergoing Emergent Cardiac Surgery

This study has been completed.
Information provided by (Responsible Party):
Medical University of Graz Identifier:
First received: October 4, 2011
Last updated: January 26, 2015
Last verified: January 2015
The aim of the study is to evaluate if there is an association between platelet inhibition and surgery-related bleeding in patients undergoing emergent cardiac surgery during dual antiplatelet therapy.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Does Platelet Inhibition Predict Surgery Related Bleeding in Patients Undergoing Emergent Cardiac Surgery During Dual Antiplatelet Therapy - a Pilot Study

Resource links provided by NLM:

Further study details as provided by Medical University of Graz:

Primary Outcome Measures:
  • Calculated blood loss [ Time Frame: until postoperative day 5 ]

Secondary Outcome Measures:
  • BARC bleeding [ Time Frame: until postoperative day 2 ]
    Intracranial bleed within 48 hours, Reoperation after closure of sternotomy for the purpose of controlling bleeding, Transfusion of equal to or more than 5 Units of packed red blood cells within a 48-hour period, Chest tube output of equal to or more than 2 L within a 24-h period.

Enrollment: 161
Study Start Date: January 2011
Study Completion Date: August 2014
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
One group
Emergency surgery

Detailed Description:
Blood for measuring platelet function is drawn before induction of anesthesia

Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients needing emergent cardiac surgery under dual antiplatelet therapy

Inclusion Criteria:

  • First time on-pump CABG with or without valve replacement

Exclusion Criteria:

  • Redo surgery,
  • Renal insufficiency needing dialysis,
  • Concomitant medication with warfarin,
  • Preoperative fibrinogen < 150 mg%
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01468597

Department of Anesthesiology and Intensive Care Medicine, Department of Surgery, Medical University of Graz
Graz, Austria, 8036
Sponsors and Collaborators
Medical University of Graz
Principal Investigator: Elisabeth Mahla, M.D. Department of Anesthesia and Intensive Care Medicine, Medical University of Graz
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Medical University of Graz Identifier: NCT01468597     History of Changes
Other Study ID Numbers: 21-202 ex 09/10
Study First Received: October 4, 2011
Last Updated: January 26, 2015

Keywords provided by Medical University of Graz:
Cardiac surgery
Platelet function

Additional relevant MeSH terms:
Pathologic Processes processed this record on April 28, 2017