Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude
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|ClinicalTrials.gov Identifier: NCT01468194|
Recruitment Status : Completed
First Posted : November 9, 2011
Last Update Posted : November 9, 2011
|Condition or disease||Intervention/treatment||Phase|
|Acute Mountain Sickness||Other: Breathing procedure 1 Other: Breathing procedure 2||Not Applicable|
Acute mountain sickness (AMS) is a pathological effect of high altitude on humans caused by acute exposure to low partial pressure of oxygen at high altitude. It commonly occurs above 2500 meters of altitude. AMS appears as a collection of nonspecific symptoms acquired at high altitude or in low air pressure resembling a case of "flu, carbon monoxide poisoning, or a hangover".
It is caused by a drop in pressure and lowering partial pressure of oxygen during increasing altitude. The direct consequence of those changes is a hypoxic pulmonary vasoconstriction (Euler-Lijestrand-mechanism). In addition a rise in pulmonary blood pressure (Hypertonia) can occur so that there is a higher risk of developing a high altitude pulmonary edema (HAPE).
In this investigation the investigators are exploring whether different types of breathing procedures can improve the peripheral oxygen saturation. We are comparing breathing with no regulation with two different procedures of hyperventilation during trekking in different altitudes. Procedure 1 (hyperventilation 1) describes inhalation during one step and exhalation during the next step. Procedure 2 (hyperventilation 2) describes inhalation and exhalation during one step.
The effect of the different breathing procedures can be quantified measuring the peripheral oxygen saturation. In addition the investigators are comparing the breathing rate and the minute ventilation as well as the expiratory end-tidal CO2-partial pressure of the three different breathing procedures.
Furthermore, the investigators are examining the ability to concentrate in order to quantify the effect of AMS on organ functions.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Single (Outcomes Assessor)|
|Study Start Date :||July 2011|
|Actual Primary Completion Date :||October 2011|
|Actual Study Completion Date :||November 2011|
Experimental: Breathing procedure 1
Walking with breathing procedure "1".
Other: Breathing procedure 1
inhalation during one step, exhalation during the next step
Experimental: Breathing procedure 2
Walking with breathing procedure "2".
Other: Breathing procedure 2
inhalation and exhalation during one step
No Intervention: Control group
Walking without any reglementation of breathing
- change of peripheral oxygen saturation [ Time Frame: immediate after intervention ]change of peripheral oxygen saturation under different breathing procedures in different altitudes
- change of breathing parameters [ Time Frame: immediate after intervention ]
change of breathing parameters under different breathing procedures in different altitudes
- breathing rate
- minute ventilation
- expiratory end-tidal CO2-partial pressure
- change of cognition [ Time Frame: immediate after intervention ]change of ability of cognition (measured by d2-test) under different breathing procedures in different altitudes
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01468194
|University of Giessen|
|Giessen, Hessen, Germany, 35394|
|Principal Investigator:||Gabor Szalay, Dr. med.||Trauma surgery - University hospital Giessen|