The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase
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|ClinicalTrials.gov Identifier: NCT01467674|
Recruitment Status : Completed
First Posted : November 9, 2011
Last Update Posted : November 9, 2011
|Condition or disease|
|Type 2 Diabetes Mellitus Chronic Periodontitis|
Reactive oxygen species (ROS) are products of normal cellular metabolism and play beneficial role in physiological functions. Overproduction of ROS and/or deficiency of enzymatic or non-enzymatic antioxidants, termed as oxidative stress, is involved in many pathological conditions such as Diabetes mellitus (DM) and chronic periodontitis (CP).
Several researches revealed that DM, with many determinants such as level of glycemic control, stands as a strong risk factor for periodontal diseases. On the other side, periodontal diseases induce an elevated chronic inflammatory state and exacerbated insulin resistance.
In the present study, the investigators examined the effect of glycemic control level on clinical periodontal status, levels of MDA, GSH-Px, GSH and PON activity in gingival crevicular fluid and blood samples of CP patients with T2DM.
|Study Type :||Observational|
|Actual Enrollment :||84 participants|
|Observational Model:||Case Control|
|Official Title:||Malondialdehyde And Antioxidant Levels In Chronic Periodontitis Patients With Type 2 Diabetes Mellitus Under Different Stages Of Metabolic Control|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||May 2009|
|Actual Study Completion Date :||May 2009|
|Better Controlled T2DM|
|Poor Controlled T2DM|
- HbA1c [ Time Frame: One Year ]Level of Metabolic Control
- Clinical Periodontal Status [ Time Frame: One Year ]Periodontal indices evaluating clinical periodontal health status
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01467674
|Suleyman Demirel University|
|Isparta, Turkey, 32260|
|Study Director:||F. Yeşim Kırzıoğlu, 1||Professor, Periodontology Dept|
|Study Director:||Mustafa Nazıroğlu, 1||Professor, Biophysics Dept|
|Study Director:||M. Numan Tamer, 1||Professor, Internal Diseases Dept.|