The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase
The aim of this study was to investigate the impact of glycemic control on clinical periodontal status, levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) and paraoxonase (PON) activity in gingival crevicular fluid (GCF) and blood samples of type 2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP).
Type 2 Diabetes Mellitus
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Malondialdehyde And Antioxidant Levels In Chronic Periodontitis Patients With Type 2 Diabetes Mellitus Under Different Stages Of Metabolic Control|
- HbA1c [ Time Frame: One Year ] [ Designated as safety issue: No ]Level of Metabolic Control
- Clinical Periodontal Status [ Time Frame: One Year ] [ Designated as safety issue: No ]Periodontal indices evaluating clinical periodontal health status
|Study Start Date:||January 2008|
|Study Completion Date:||May 2009|
|Primary Completion Date:||May 2009 (Final data collection date for primary outcome measure)|
|Better Controlled T2DM|
|Poor Controlled T2DM|
Reactive oxygen species (ROS) are products of normal cellular metabolism and play beneficial role in physiological functions. Overproduction of ROS and/or deficiency of enzymatic or non-enzymatic antioxidants, termed as oxidative stress, is involved in many pathological conditions such as Diabetes mellitus (DM) and chronic periodontitis (CP).
Several researches revealed that DM, with many determinants such as level of glycemic control, stands as a strong risk factor for periodontal diseases. On the other side, periodontal diseases induce an elevated chronic inflammatory state and exacerbated insulin resistance.
In the present study, the investigators examined the effect of glycemic control level on clinical periodontal status, levels of MDA, GSH-Px, GSH and PON activity in gingival crevicular fluid and blood samples of CP patients with T2DM.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01467674
|Suleyman Demirel University|
|Isparta, Turkey, 32260|
|Study Director:||F. Yeşim Kırzıoğlu, 1||Professor, Periodontology Dept|
|Study Director:||Mustafa Nazıroğlu, 1||Professor, Biophysics Dept|
|Study Director:||M. Numan Tamer, 1||Professor, Internal Diseases Dept.|