Evaluation of Intravenous N-acetylcysteine to Prevent Contrast Media Induced Nephrotoxicity in an Emergency Center

This study has been completed.
Information provided by (Responsible Party):
Poletti Pierre-Alexandre, University Hospital, Geneva
ClinicalTrials.gov Identifier:
First received: November 3, 2011
Last updated: November 8, 2011
Last verified: November 2011
The aim of the present study is to determine whether a high dose of intravenous NAC is efficient in preventing CN after emergency contrast injection in patients with renal failure.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Does Ultra-High Dose i.v. N-acetylcysteine Prevent Contrast Nephropathy in Patients With Chronic Kidney Disease Undergoing Emergency Contrast Tomography.

Resource links provided by NLM:

Further study details as provided by University Hospital, Geneva:

Primary Outcome Measures:
  • occurrence of contrast nephropathy at day 2, 4 or 10, which was defined as an increase of at least 25% and/or 44 umol/l in serum creatinine level or cystatine C levels at day 2, 4 or 10 compared to day 0. [ Time Frame: 10 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • mean increases in creatinine and cystatin C concentrations on days 2, 4 and 10 and maximum increase during the time periods from day 2 to day 10 (peak increase). [ Time Frame: 10 days ] [ Designated as safety issue: No ]

Enrollment: 124
Study Start Date: May 2008
Study Completion Date: November 2011
Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Control group
NAC group

  Show Detailed Description


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
emergency center patients

Inclusion Criteria:

  • Renal failure and need of contrast enhanced CT

Exclusion Criteria:

  • Asthma
  • Pregnancy
  • Obstructive nephropathy
  • Patient or family's refusal
  • In all patients
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01467154

Sponsors and Collaborators
University Hospital, Geneva
Principal Investigator: Pierre-Alexandre Poletti, MD University Hospital, Geneva
  More Information

No publications provided by University Hospital, Geneva

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Poletti Pierre-Alexandre, MD, University Hospital, Geneva
ClinicalTrials.gov Identifier: NCT01467154     History of Changes
Other Study ID Numbers: 2008DR4057 
Study First Received: November 3, 2011
Last Updated: November 8, 2011
Health Authority: Switzerland: Swissmedic

Additional relevant MeSH terms:
Anti-Infective Agents
Antiviral Agents
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Protective Agents
Respiratory System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on February 04, 2016