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Evaluation of Intravenous N-acetylcysteine to Prevent Contrast Media Induced Nephrotoxicity in an Emergency Center

This study has been completed.
Information provided by (Responsible Party):
Poletti Pierre-Alexandre, University Hospital, Geneva Identifier:
First received: November 3, 2011
Last updated: November 8, 2011
Last verified: November 2011
The aim of the present study is to determine whether a high dose of intravenous NAC is efficient in preventing CN after emergency contrast injection in patients with renal failure.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Does Ultra-High Dose i.v. N-acetylcysteine Prevent Contrast Nephropathy in Patients With Chronic Kidney Disease Undergoing Emergency Contrast Tomography.

Resource links provided by NLM:

Further study details as provided by Poletti Pierre-Alexandre, University Hospital, Geneva:

Primary Outcome Measures:
  • occurrence of contrast nephropathy at day 2, 4 or 10, which was defined as an increase of at least 25% and/or 44 umol/l in serum creatinine level or cystatine C levels at day 2, 4 or 10 compared to day 0. [ Time Frame: 10 days ]

Secondary Outcome Measures:
  • mean increases in creatinine and cystatin C concentrations on days 2, 4 and 10 and maximum increase during the time periods from day 2 to day 10 (peak increase). [ Time Frame: 10 days ]

Enrollment: 124
Study Start Date: May 2008
Study Completion Date: November 2011
Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Control group
NAC group

  Show Detailed Description


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
emergency center patients

Inclusion Criteria:

  • Renal failure and need of contrast enhanced CT

Exclusion Criteria:

  • Asthma
  • Pregnancy
  • Obstructive nephropathy
  • Patient or family's refusal
  • In all patients
  Contacts and Locations
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Please refer to this study by its identifier: NCT01467154

Sponsors and Collaborators
University Hospital, Geneva
Principal Investigator: Pierre-Alexandre Poletti, MD University Hospital, Geneva
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Poletti Pierre-Alexandre, MD, University Hospital, Geneva Identifier: NCT01467154     History of Changes
Other Study ID Numbers: 2008DR4057
Study First Received: November 3, 2011
Last Updated: November 8, 2011

Additional relevant MeSH terms:
Disease Attributes
Pathologic Processes
Antiviral Agents
Anti-Infective Agents
Respiratory System Agents
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs
Antidotes processed this record on September 20, 2017