The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body. The investigators will also examine the impact of any anxiety, depression, and stress related symptoms on learning processes.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
|Official Title:||The Effect of Oxytocin on Fear Memory Consolidation: A Novel Intervention to Prevent PTSD|
- Physiological reactivity as measured by skin conductance, heart rate, and corrugator EMG [ Time Frame: Day 2 of Conditioning (1 day post Day 1 of Conditioning) ] [ Designated as safety issue: No ]Differences in physiological reactivity between the active vs. placebo conditions will be used to assess for the impact of oxytocin on fear renewal and reinstatement.
|Study Start Date:||October 2011|
|Study Completion Date:||May 2014|
|Primary Completion Date:||May 2014 (Final data collection date for primary outcome measure)|
Placebo Comparator: Placebo
Matched nasal spray placebo.
Matched nasal spray placebo
Liquid intranasal oxytocin administered in a nasal spray.
Liquid metered-dose nasal spray, 30 IUs, administered once.
Other Name: Syntocinon
Please refer to this study by its ClinicalTrials.gov identifier: NCT01466127
|United States, Massachusetts|
|Center for Anxiety and Traumatic Disorders, MGH|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Elizabeth A Hoge, MD||Massachusetts General Hospital|