Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude (PerOxySleep)

This study has been completed.
Information provided by (Responsible Party):
Peter Stein, Goethe University Identifier:
First received: October 26, 2011
Last updated: April 4, 2012
Last verified: April 2012

One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration. It usually takes a prolonged stay at a constant altitude to adapt sufficiently to the altitude and to have a refreshing night sleep. 1975 Reit et. al showed in their EEG-recordings that the sleep architecture (the regular succession of the particular sleep phases) is disturbed by repeating arousals which occur due to an irregularity in the breathing rhythm.

The purpose of this study is to create a better understanding of the underlying mechanisms that lead to failed acclimatization and AMS, due to sleep disturbance.

Environmental Sleep Disorder
Cheyne-Stokes Respiration
Altitude Sickness

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During the Sleep in High Altitude

Resource links provided by NLM:

Further study details as provided by Goethe University:

Primary Outcome Measures:
  • Tissue oxygenation index [ Time Frame: participants will be followed for the duration of the expedition, an expected 7 days ] [ Designated as safety issue: No ]
    Measured with near infra-red spectroscopy

Secondary Outcome Measures:
  • Tissue hemoglobin index [ Time Frame: participants will be followed for the duration of the expedition, an expected 7 days ] [ Designated as safety issue: No ]
    measured with near infra-red spectroscopy

Enrollment: 6
Study Start Date: May 2011
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
not acclimatized
no stay in an altitude above 2500 m within the last 3 Months
stay above 2500 m with the last 14 days

Detailed Description:

Under sea level conditions humans breath between 10 and 12 times per minute. The breathing cycle in high altitude is accelerated. If the conscious breathing control vanishes during sleep a periodic breathing with alternating episodes of hyperventilation and apnea is the result. This circumstance causes repetitive arousals that do not allow a normal sleep pattern. The associated adverse effects are fatigue, slow or failed acclimatization, weakening of the immune system, lack of motivation and the disability to make rational decisions.

Sleep deprivation is a common reason for the abortion of a trip, accidents and severe forms of Acute Mountain Sickness (AMS).


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
participants of an expedition to Mount Kilimanjaro

Inclusion Criteria:

  • Age: 18 - 80 years
  • voluntary participation in an expedition to Mount Kilimanjaro

Exclusion Criteria:

  • obstructive or restrictive respiratory disorder
  • hemodynamic relevant cardiac defect
  • sleep disorder
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Please refer to this study by its identifier: NCT01465971

Clinic for Anaesthesia, Intensive Care Medicine and Pain Therapy
Frankfurt, Hesse, Germany, 60318
Sponsors and Collaborators
Goethe University
Principal Investigator: Peter Stein, Goethe University
  More Information

Responsible Party: Peter Stein, Consultant of the Department for Anesthesiology, Intensive Care Medicine and Pain Therapy of the Goethe-University Frankfurt / Germany - Head of the working group for expedition medicine, Goethe University Identifier: NCT01465971     History of Changes
Other Study ID Numbers: ExpedMed#1-2011
Study First Received: October 26, 2011
Last Updated: April 4, 2012
Health Authority: Germany: Ethics Commission

Keywords provided by Goethe University:

Additional relevant MeSH terms:
Altitude Sickness
Cheyne-Stokes Respiration
Sleep Disorders
Mental Disorders
Nervous System Diseases
Neurologic Manifestations
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms
Signs and Symptoms, Respiratory processed this record on November 25, 2015