Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude (PerOxySleep)
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration. It usually takes a prolonged stay at a constant altitude to adapt sufficiently to the altitude and to have a refreshing night sleep. 1975 Reit et. al showed in their EEG-recordings that the sleep architecture (the regular succession of the particular sleep phases) is disturbed by repeating arousals which occur due to an irregularity in the breathing rhythm.
The purpose of this study is to create a better understanding of the underlying mechanisms that lead to failed acclimatization and AMS, due to sleep disturbance.
|Environmental Sleep Disorder Cheyne-Stokes Respiration Altitude Sickness|
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During the Sleep in High Altitude|
- Tissue oxygenation index [ Time Frame: participants will be followed for the duration of the expedition, an expected 7 days ]Measured with near infra-red spectroscopy
- Tissue hemoglobin index [ Time Frame: participants will be followed for the duration of the expedition, an expected 7 days ]measured with near infra-red spectroscopy
|Study Start Date:||May 2011|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
no stay in an altitude above 2500 m within the last 3 Months
stay above 2500 m with the last 14 days
Under sea level conditions humans breath between 10 and 12 times per minute. The breathing cycle in high altitude is accelerated. If the conscious breathing control vanishes during sleep a periodic breathing with alternating episodes of hyperventilation and apnea is the result. This circumstance causes repetitive arousals that do not allow a normal sleep pattern. The associated adverse effects are fatigue, slow or failed acclimatization, weakening of the immune system, lack of motivation and the disability to make rational decisions.
Sleep deprivation is a common reason for the abortion of a trip, accidents and severe forms of Acute Mountain Sickness (AMS).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01465971
|Clinic for Anaesthesia, Intensive Care Medicine and Pain Therapy|
|Frankfurt, Hesse, Germany, 60318|
|Principal Investigator:||Peter Stein, Dr.med.||Goethe University|