Dietetic and Hygiene Measures in Metabolic Neuropathies: the Neurodiet Study

• Change from Baseline in NTSS6 score at 3 months [ Time Frame: 3 months ]
  Change from Baseline in NTSS6 score at 3 months (Bastyr EJ, 3rd, Price KL, Bril V. Development and validity testing of the neuropathy total symptom score-6: questionnaire for the study of sensory symptoms of diabetic peripheral neuropathy. Clin Ther. 2005 Aug;27(8):1278-94)
  
  

• clinical global impression of change [ Time Frame: 3 months ]
  
• change from baseline of sensory nerve action potential and sensory and motor nerve velocity [ Time Frame: 3 months ]
  change from baseline of sensory nerve action potential and sensory and motor nerve velocity at 3 months
  
  
• change from baseline of thermal and vibration thresholds [ Time Frame: 3 months ]
  

Metabolic disorder such as diabetes mellitus, glucose intolerance and possibly metabolic syndrome can induce a peripheral neuropathy. The objectives of the present study are to investigate:

1. the effect of physical training and diet education on neuropathic symptoms and neurophysiological parameters
2. the best coaching modality of education.

This will be a prospective single blind study (blinded evaluator). Patients will be randomly assigned in two groups. The first group will have a one-day therapeutic education program followed by a 5-minutes phone call every week for 3 months. The second group will have the same one-day therapeutic education program that will be followed by an unique one-hour phone call. During the one-day therapeutic education program and the phone calls, hygienic rules (ie physical activities) and dietetic regimen advices will be given to patients. Evaluation will be done at 3 months.