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MicroRNA Expression in Human Blood Serum and Vitreous Body

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01462734
First Posted: October 31, 2011
Last Update Posted: April 1, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Kazunari Hirota, Kyorin University
  Purpose
MicroRNAs are important regulators of many cellular functions but their expression profile in human vitreous is still unclear. Aim of this study is to investigate microRNA expression profile by PCR in human vitreous of macula hole patients which is suggested to be similar to that of healthy patients.

Condition Intervention
MicroRNA Expression Profile in Human Vitreous Procedure: human vitreous and blood serum sampling, PCR

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: MicroRNA Expression in Human Blood Serum and Vitreous Body

Further study details as provided by Kazunari Hirota, Kyorin University:

Primary Outcome Measures:
  • MicroRNA expression profile in human vitreous investigated by PCR [ Time Frame: 1month ]

Biospecimen Retention:   Samples With DNA
3ml of blood serum and 1ml of vitreous

Enrollment: 8
Study Start Date: October 2011
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
human vitreous, human blood serum, PCR
Vitreous and bloodserum samples from macula hole patients without previous ocular or systemic disease
Procedure: human vitreous and blood serum sampling, PCR
1ml of human vitreous and 3ml of human blood serum

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Female pateints undergoing vitrectomy for macula hole without previous ocular or systemic disease
Criteria

Inclusion Criteria:

  • Female macula hole patients without previous ocular or systemic disease.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01462734


Locations
Japan
Kyorin University School Of Medicine
Tokyo, Mitakasi Sinkawa6-20-2, Japan, 181-8611
Sponsors and Collaborators
Kyorin University
  More Information

Responsible Party: Kazunari Hirota, MD, Kyorin University
ClinicalTrials.gov Identifier: NCT01462734     History of Changes
Other Study ID Numbers: No. 461
First Submitted: October 26, 2011
First Posted: October 31, 2011
Last Update Posted: April 1, 2015
Last Verified: March 2015