Aortic Calcification - is it a Marker for Carotid Artery Stenosis?

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01458860
Recruitment Status : Unknown
Verified October 2011 by Ziv Hospital.
Recruitment status was:  Not yet recruiting
First Posted : October 25, 2011
Last Update Posted : November 1, 2011
Information provided by (Responsible Party):
Ziv Hospital

Brief Summary:

Atherosclerosis is the major contributor for the morbidity and mortality for the variety of cardiovascular diseases.

Aortic calcification on x-ray is a marker for arterial atherosclerosis and an independent prognostic factor for the morbidity and mortality from a cardiovascular event.

Carotid artery stenoses is the current accepted indication for interventional treatment of carotid artery, for the prevention of embolic event, while other arterial atherosclerosis indication, is for hemodynamic disturbance and ischemic outcome.

This research will try to find whether incidental aortic calcification can predict carotid artery stenosis.

Two groups will be chosen: group A - patients who had CT scan in the hospital (for different indications); Group B - patients (not from the first group) who have a significant carotid artery stenosis who are indicated for interventional treatment.

The data to analyze:

Group A - Patients with aortic calcification, carotid artery stenosis, and patients with both Group B - Patients who have aortic calcification Comparison of the populations within the group and among the two will show if a significant correlation between aortic calcification and carotid artery stenosis exist.

Condition or disease
Carotid Artery Stenosis Aortic Calcification

Detailed Description:

Background - thoracic or abdominal aortic calcification is a documented independent risk factor for cardiovascular atherosclerotic disease and increased death.

Atherosclerosis is a diffuse multicentric disease in the arterial tree, affecting target organs (heart, aorta, lower extremities, carotid arteries etc.). Mostly located in arterial bifurcations (Iliac and carotid artery bifurcations) or in constant repetitive arterial trauma (Adductors tendon, Hunter's canal). The invasive treatment (endovascular, surgery) is preserved for patients with critical arterial stenosis or occlusion in symptomatic patients. Exceptions are the carotid arteries: the majority of patients with a severe internal carotid artery stenosis are asymptomatic patients, which are treated for the prevention embolic events (TIA's or CVA's).

Current articles are observational, and describe retrospectively the morbidity and mortality from atherosclerosis with aortic calcification.

the investigators assumption is that if aortic calcification is a marker for diffuse atherosclerosis, it has good correlation to criptogenous carotid artery disease, and can lead to early carotid artery disease evaluation and treatment.

Purpose - to find a reliable correlation between aortic calcification, and carotid artery stenosis (from atherosclerosis)

Method - two groups will be evaluated:

Group A - patients (age >40 years), that had a CT scan (chest/abdomen) for any indication, will be evaluated for aortic calcifications. The patients will be additionally examined for carotid artery stenosis by Doppler ultrasound. (100 patients) Group B - Patients that were diagnosed by Doppler ultrasound, and were found to have a severe carotid artery stenosis. These patients are scheduled for a computed tomography-angiography (regardless for the research) of the cervical arteries, will be additionally complete abdominal/chest tomography scan, without additional contrast. (50 patients).

Results - will be statistically evaluated - Group A - number of patients with aortic calcification, number of patients with carotid artery stenosis; Group B - Number of patients that have associated aortic calcification.

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Aortic Calcification - is it a Marker for Carotid Artery Stenosis?
Study Start Date : February 2012
Estimated Primary Completion Date : February 2012
Estimated Study Completion Date : February 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Minerals
U.S. FDA Resources

patients had a CT
patients with severe carotid artery stenosis

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Group A - patients who had a CT scan Group B - patients who have severe carotid artery stenosis

Inclusion Criteria:

Group A - patients, age 40-99 years, that had a CT scan for any indication Group B - patients with severe carotid artery stenosis, that indicated for treatment

Exclusion Criteria:

  • Group A - age <40 years
  • Group B - carotid artery stenosis, without intention-to-treat

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01458860

Sponsors and Collaborators
Ziv Hospital
Principal Investigator: Tal Salamon, MD Zim medical center
Study Director: Alexander Altsuler, MD Ziv Medical Center

Responsible Party: Ziv Hospital Identifier: NCT01458860     History of Changes
Other Study ID Numbers: ZIV-11-0041
First Posted: October 25, 2011    Key Record Dates
Last Update Posted: November 1, 2011
Last Verified: October 2011

Additional relevant MeSH terms:
Constriction, Pathologic
Carotid Stenosis
Pathological Conditions, Anatomical
Calcium Metabolism Disorders
Metabolic Diseases
Carotid Artery Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases