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Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease (MMACKD)

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ClinicalTrials.gov Identifier: NCT01458158
Recruitment Status : Unknown
Verified February 2015 by Grigorios G. DIMAS, Aristotle University Of Thessaloniki.
Recruitment status was:  Recruiting
First Posted : October 24, 2011
Last Update Posted : February 23, 2015
Sponsor:
Collaborator:
AHEPA University Hospital
Information provided by (Responsible Party):
Grigorios G. DIMAS, Aristotle University Of Thessaloniki

Brief Summary:
The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.

Condition or disease
Diabetic Nephropathy

Detailed Description:
The purpose of this study is to determine the correlation of matrix metalloproteinases and atherosclerosis of chronic kidney disease. Patients with diabetes mellitus type 2,as a non-inflammatory leading cause of end stage renal failure and patients with chronic glomerulonephritis and similar course of proteinuria,as an inflammatory leading cause of end stage renal failure are enrolled.

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Role of Matrix Metalloproteinases -2 and -9 in Atherosclerosis of Patients With Chronic Kidney Disease
Study Start Date : October 2011
Estimated Primary Completion Date : May 2016
Estimated Study Completion Date : May 2016

Resource links provided by the National Library of Medicine


Group/Cohort
Diabetic nephropathy
Diabetic nephropathy in patients with type 2 diabetes
chronic glomerulonephritis
chronic glomerulonephritis in patients without diabetes mellitus
controls
participants without diabetic nephropathy and chronic glomerulonephritis



Primary Outcome Measures :
  1. Association of matrix metalloproteinases with atherosclerosis in patients with chronic kidney disease [ Time Frame: two years ]
    Matrix metalloproteinases associated with atherosclerosis in chronic kidney disease;patients with diabetes mellitus type 2 and others with chronic glomerulonephritis.Serum levels of MMPs-2 and -9 are measured by an ELISA system.Intima Media Thickness(IMT) of carotid and femoral arteries is measured with a high resolution ultrasonography.


Secondary Outcome Measures :
  1. Matrix metalloproteinases and atherosclerosis associated with pro-inflammatory and oxidative stress markers in chronic kidney disease [ Time Frame: two years ]
    Matrix metalloproteinases associated with atherosclerosis markers,pro-inflammatory markers and markers of oxidative stress in chronic kidney disease


Biospecimen Retention:   Samples Without DNA
serum and vessels


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Ages Eligible for Study:   50 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients from University Hospital AHEPA
Criteria

Inclusion Criteria:

  • Chronic kidney disease
  • Diabetes mellitus type 2

Exclusion Criteria:

  • Malignancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01458158


Contacts
Contact: Grigorios G. Dimas +0030 6972321534 gregorydimas@yahoo.gr

Locations
Greece
AHEPA University Hospital, Medical School of Aristotle University of Thessaloniki Recruiting
Thessaloniki, Greece
Principal Investigator: Grigorios G. Dimas, MD         
Sponsors and Collaborators
Aristotle University Of Thessaloniki
AHEPA University Hospital
Investigators
Principal Investigator: Grigorios G. Dimas, MD AHEPA University Hospital,Medical School of Aristotle University of Thessaloniki

Responsible Party: Grigorios G. DIMAS, Doctor/PhD Candidate, Aristotle University Of Thessaloniki
ClinicalTrials.gov Identifier: NCT01458158     History of Changes
Other Study ID Numbers: A13749
31-8-2010 ( Other Identifier: AristotleU )
First Posted: October 24, 2011    Key Record Dates
Last Update Posted: February 23, 2015
Last Verified: February 2015

Keywords provided by Grigorios G. DIMAS, Aristotle University Of Thessaloniki:
Gelatinases
kidney disease
diabetes mellitus type 2

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Atherosclerosis
Diabetic Nephropathies
Urologic Diseases
Renal Insufficiency
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases