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Prevalence of Pulmonary Embolism in ICU (PEICU)

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Grenoble Identifier:
First received: October 20, 2011
Last updated: October 21, 2011
Last verified: October 2011
The primary objective of this study was to estimate the prevalence of PE among consecutive ICU patients receiving MV who required thoracic computed tomography (CT) with contrast agent injection, regardless of whether PE was suspected clinically. The secondary objectives were to assess the association between PE and DVT, to identify risk factors for VTE, and to determine the outcome of VTE.

Pulmonary Embolism
Deep Venous Thrombosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Pulmonary Embolism in Mechanically Ventilated Patients Requiring Computed Tomography: Prevalence, Risk Factors and Outcome

Resource links provided by NLM:

Further study details as provided by University Hospital, Grenoble:

Primary Outcome Measures:
  • Find a pulmonary embolism on the CT scan [ Time Frame: CT scan at the day of inclusion ]
    TO estimate the prevalence of PE among consecutive ICU patients receiving MV who required thoracic computed tomography (CT) with contrast agent injection, regardless of whether PE was suspected clinically.

Secondary Outcome Measures:
  • To find thrombus on compression ultrasound (CUS) of the four limbs [ Time Frame: CUS within 48 hours after the CT scan ]

Enrollment: 176
Study Start Date: December 2009
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
pulmonary embolism, deep venous thrombosis

Detailed Description:

Background: Pulmonary embolism (PE) produces nonspecific or minimal symptoms in mechanically ventilated (MV) patients, leading to underdiagnosis. We estimated the prevalence of PE and associations with deep vein thrombosis (DVT) among MV patients.

Methods: Consecutive MV patients who required thoracic computed tomography (CT) in a single ICU. Compression ultrasound of the four limbs was performed within 48 hours of inclusion. Curative anticoagulation therapy was given immediately after PE diagnosis.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients in ICU, mecanically ventilated with a CT scab with iodine injection

Inclusion Criteria:

  • all patients requiring invasive MV and thoracic contrast-enhanced CT for any reason

Exclusion Criteria:

  • a diagnosis of PE before ICU admission,
  • allergy to contrast agents,
  • and age younger than 18 years.
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Please refer to this study by its identifier: NCT01457963

University hospital of grenoble
Grenoble, France, 38043
Sponsors and Collaborators
University Hospital, Grenoble
Principal Investigator: Jean Francois TIMSIT, PU/PH University Hospital, Grenoble
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University Hospital, Grenoble Identifier: NCT01457963     History of Changes
Other Study ID Numbers: 5891
Study First Received: October 20, 2011
Last Updated: October 21, 2011

Additional relevant MeSH terms:
Venous Thrombosis
Pulmonary Embolism
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases processed this record on May 22, 2017