Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients (COMED)
|ClinicalTrials.gov Identifier: NCT01456533|
Recruitment Status : Completed
First Posted : October 20, 2011
Last Update Posted : December 2, 2015
Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging.
Osmotically inadequate secretion of antidiuretic hormone (ADH) is the predominant mechanism in most dysnatremic disorders. ADH measurement is cumbersome. It is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of ADH.
Objective: To evaluate the additional value of copeptin to improve a currently used algorithm in the differential diagnosis of (A) severe hypoosmolar hypo- and (B) severe hypernatremia.
Design: Prospective observational study.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||300 participants|
|Official Title:||Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients|
|Study Start Date :||October 2011|
|Primary Completion Date :||April 2015|
|Study Completion Date :||April 2015|
hospitalized patients with hyponatremia
- diagnostic accuracy of copeptin within hospital stay [ Time Frame: participants will be followed for up to 1 year ]diagnostic accuracy will be determined by receiver operated curve (ROC) analysis. The study is powered to detect a difference of copeptin levels between patients with partial central diabetes insipidus (DI) and patients with primary polydipsia.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01456533
|Aarau, Aargau, Switzerland|
|Basel, Switzerland, 4031|
|Principal Investigator:||Mirjam Christ-Crain, MD, PhD||University Hospital, Basel, Switzerland|
|Principal Investigator:||Beat Müller, MD||Kantonsspital Aarau, University Hospital Basel|