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Volumetric Monitoring in Major Lung Surgery (EVLW-PNEUMO)

This study has been completed.
Regional hospital of Arkhangelsk
University of Tromso
Information provided by (Responsible Party):
Vsevolod V. Kuzkov, Northern State Medical University Identifier:
First received: October 17, 2011
Last updated: September 4, 2012
Last verified: September 2012
The hypothesis of this observational single-center clinical study was to explore the volumetric hemodynamic monitoring in the perioperative period in major and risky thoracic intervention. The investigators monitored the changes in the volumes of blood in the central vessels and heart chambers as well as a volume of fluid in pulmonary tissue (i. e. extravascular lung water).

Acute Pulmonary Edema

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Pulmonary Edema Following Major Thoracic Resections: a Value of Perioperative Volumetric Monitoring

Resource links provided by NLM:

Further study details as provided by Vsevolod V. Kuzkov, Northern State Medical University:

Biospecimen Retention:   Samples Without DNA
Blood plasma for non-specified additional retrospective tests.

Estimated Enrollment: 50
Study Start Date: June 2005
Study Completion Date: November 2011
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Detailed Description:
The goal of this observational study is to investigate into changes in volumetric hemodynamic parameters obtained with a technique of transpulmonary indicator dilution after major thoracic intervention, including pneumonectomy and lobar resections. The important parameters of hemodynamics were monitored throughout the intervention and 48 hrs postoperatively, including extravascular lung water index, global end-diastolic volume index, etc.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study population includes the patients scheduled for extended thoracic resections (lobar resection and pneumonectomy) due to bronchial cancer or severe destructive pulmonary infection (abscess and/or pneumonia).

Inclusion Criteria:

  • Informed consent
  • Age above 18 and below 80
  • Confirmed malignant bronchial neoplasm or
  • Destructive pulmonary infection

Exclusion Criteria:

  • Pregnant
  • Severe pulmonary hypertension
  • Pulmonary tuberculosis
  • Severe occlusive atherosclerosis of lower extremities
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Please refer to this study by its identifier: NCT01455766

Russian Federation
Regional Hospital of Arkhangelsk
Arkhangelsk, Arkhangelsk Region, Russian Federation, 163000
Sponsors and Collaborators
Northern State Medical University
Regional hospital of Arkhangelsk
University of Tromso
Principal Investigator: Vsevolod V. Kuzkov, MD, PhD Northern State Medical University
Principal Investigator: Mikhail M. Orlov, MD Regional hospital of Arkhangelsk
Study Chair: Mikhail Y. Kirov, MD, PhD Northern State Medical University
Study Director: Lars J. Bjertnaes, MD, PhD University of Trmsoe, Tromsoe, Norway
  More Information

Responsible Party: Vsevolod V. Kuzkov, Associate Professor, MD, PhD, Northern State Medical University Identifier: NCT01455766     History of Changes
Other Study ID Numbers: 2005-2011
Study First Received: October 17, 2011
Last Updated: September 4, 2012

Keywords provided by Vsevolod V. Kuzkov, Northern State Medical University:
postpneumonectomy pulmonary edema
extravascular lung water

Additional relevant MeSH terms:
Pulmonary Edema
Signs and Symptoms
Lung Diseases
Respiratory Tract Diseases processed this record on May 25, 2017