In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome
Muscular compartment syndrome (MCS) is consecutive to an increase in intramuscular compartment pressures, and is a rare but serious postoperative complication.
The INVOS (In Vivo Optical Spectroscopy) monitors tissular oxygenation continuously and non-invasively.
The objective is to develop a model mimicking the physiopathology of MCS to assess the interest of the INVOS in this case.
|Human Volunteers||Device: Tourniquet Device: INVOS assessment Device: EMG assessment||Phase 1|
|Study Design:||Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
|Official Title:||In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome.|
- Comparison Between INVOS Monitoring and Electromyography [ Time Frame: 45 minutes ]
A comparison will be made between the INVOS monitoring and non invasive (transcutaneous) EMG monitoring (AP Block), to determine the accuracy of the INVOS monitoring to predict AP block.
[mean (SD)] INVOS (in %) value at baseline and at the time of the block
- Intracompartmental Pressure (ICP) [ Time Frame: 45 minutes ][mean (SD)] ICP (in mmHg), value at baseline and at the time of the block
|Study Start Date:||October 2011|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
Inflation of a tourniquet
Inflation of a tourniquet (pressure equal to the mean arterial pressure) obtaining a model of slight venous congestion and arterial hypoperfusionDevice: INVOS assessment
Near Infraread spectroscopy, non invasiveDevice: EMG assessment
Electromyography, non invasive
Please refer to this study by its ClinicalTrials.gov identifier: NCT01452425
|Cliniques universitaires Saint-Luc|
|Brussels, Belgium, 1200|
|Principal Investigator:||Patrice Forget, M.D.||UCL|