We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01452217
First Posted: October 14, 2011
Last Update Posted: October 14, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Nottingham
  Purpose
Alterations in pancreatic blood have been implicated in pancreatic inflammation and pain. Several modalities have been used to assess pancreatic blood flow although some of these methods are invasive, use ionising radiation or intravenous contrast media. This is the first study to utilise non-invasive magnetic resonance imaging to quantify flow within arteries supplying the pancreas and pancreatic perfusion is response to secretin stimulation.

Condition Intervention Phase
Chronic Pancreatitis Drug: Secretin Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: The Use of Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers

Resource links provided by NLM:


Further study details as provided by University of Nottingham:

Primary Outcome Measures:
  • Pancreatic perfusion [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Overall perfusion of the pancreas


Secondary Outcome Measures:
  • Superior mesenteric artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the superior mesenteric artery

  • Gastroduodenal artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the gastroduodenal artery

  • Hepatic artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the hepatic artery

  • Splenic artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the splenic artery


Enrollment: 12
Study Start Date: September 2010
Study Completion Date: October 2011
Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Secretin Drug: Secretin
Secretin 1 IU/kg over 3 min

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male
  • Healthy
  • Able to give informed consent

Exclusion Criteria:

  • Current illness
  • Contraindications to magnetic resonance imaging
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01452217


Locations
United Kingdom
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Sponsors and Collaborators
University of Nottingham
Investigators
Principal Investigator: John Simpson, PhD FRCS University of Nottingham
  More Information

Publications:

Responsible Party: University of Nottingham
ClinicalTrials.gov Identifier: NCT01452217     History of Changes
Other Study ID Numbers: D/07/2010
First Submitted: October 10, 2011
First Posted: October 14, 2011
Last Update Posted: October 14, 2011
Last Verified: October 2011

Keywords provided by University of Nottingham:
Pancreas
Chronic pancreatitis
Perfusion
Blood flow
Magnetic resonance imaging

Additional relevant MeSH terms:
Pancreatitis
Pancreatitis, Chronic
Pancreatic Diseases
Digestive System Diseases
Secretin
Gastrointestinal Agents
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs