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Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers

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ClinicalTrials.gov Identifier: NCT01452217
Recruitment Status : Completed
First Posted : October 14, 2011
Last Update Posted : October 14, 2011
Sponsor:
Information provided by (Responsible Party):
University of Nottingham

Brief Summary:
Alterations in pancreatic blood have been implicated in pancreatic inflammation and pain. Several modalities have been used to assess pancreatic blood flow although some of these methods are invasive, use ionising radiation or intravenous contrast media. This is the first study to utilise non-invasive magnetic resonance imaging to quantify flow within arteries supplying the pancreas and pancreatic perfusion is response to secretin stimulation.

Condition or disease Intervention/treatment Phase
Chronic Pancreatitis Drug: Secretin Phase 1

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: The Use of Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers
Study Start Date : September 2010
Primary Completion Date : September 2011
Study Completion Date : October 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pancreatitis
U.S. FDA Resources

Arm Intervention/treatment
Experimental: Secretin Drug: Secretin
Secretin 1 IU/kg over 3 min



Primary Outcome Measures :
  1. Pancreatic perfusion [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Overall perfusion of the pancreas


Secondary Outcome Measures :
  1. Superior mesenteric artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the superior mesenteric artery

  2. Gastroduodenal artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the gastroduodenal artery

  3. Hepatic artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the hepatic artery

  4. Splenic artery blood flow [ Time Frame: 0, 5, 10, 20, 30 and 40 min ]
    Blood flow in the splenic artery



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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male
  • Healthy
  • Able to give informed consent

Exclusion Criteria:

  • Current illness
  • Contraindications to magnetic resonance imaging

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01452217


Locations
United Kingdom
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Sponsors and Collaborators
University of Nottingham
Investigators
Principal Investigator: John Simpson, PhD FRCS University of Nottingham

Publications:

Responsible Party: University of Nottingham
ClinicalTrials.gov Identifier: NCT01452217     History of Changes
Other Study ID Numbers: D/07/2010
First Posted: October 14, 2011    Key Record Dates
Last Update Posted: October 14, 2011
Last Verified: October 2011

Keywords provided by University of Nottingham:
Pancreas
Chronic pancreatitis
Perfusion
Blood flow
Magnetic resonance imaging

Additional relevant MeSH terms:
Pancreatitis
Pancreatitis, Chronic
Pancreatic Diseases
Digestive System Diseases
Secretin
Gastrointestinal Agents
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs