Human Skin Aging: Clinical Parameters and Gene Expression Profiling (GEP)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Anne Chang, Stanford University Identifier:
First received: October 11, 2011
Last updated: February 5, 2015
Last verified: February 2015
Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.


Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Human Skin Aging: Clinical Parameters and Gene Expression Profiling

Resource links provided by NLM:

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Assessment of age related gene expression changes in skin [ Time Frame: Cross sectional ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA
Blood and skin samples

Estimated Enrollment: 120
Study Start Date: May 2010
Estimated Study Completion Date: April 2015
Estimated Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Healthy females aged >=18
Healthy female volunteers of skin type I or II

Detailed Description:
This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy females age 18 or older

Inclusion Criteria:

  • healthy female, age 18 or older,
  • Fitzpatrick type 1 or 2 skin,
  • able to read and understand written consent form,
  • body mass index normal or overweight range,
  • willing to take blood tests and donate skin samples

Exclusion Criteria:

  • pregnant or lactating,
  • history of cosmetic surgery affecting the face,
  • use of prescription anti-aging medications for 2 weeks prior to study,
  • use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,
  • medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01451476

United States, California
Stanford Dermatology
Redwood City, California, United States, 94603
Sponsors and Collaborators
Stanford University
Principal Investigator: Alfred Lane, MD Stanford University
Study Director: Anne Chang, MD Stanford University
  More Information

No publications provided

Responsible Party: Anne Chang, instructor, Stanford University Identifier: NCT01451476     History of Changes
Other Study ID Numbers: HSA_GEP, 003
Study First Received: October 11, 2011
Last Updated: February 5, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by Stanford University:
Ageing processed this record on November 25, 2015