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Human Skin Aging: Clinical Parameters and Gene Expression Profiling (GEP)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01451476
Recruitment Status : Completed
First Posted : October 13, 2011
Last Update Posted : April 19, 2016
Information provided by (Responsible Party):
Anne Chang, Stanford University

Brief Summary:
Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.

Condition or disease

Detailed Description:
This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.

Study Type : Observational
Actual Enrollment : 122 participants
Time Perspective: Cross-Sectional
Official Title: Human Skin Aging: Clinical Parameters and Gene Expression Profiling
Study Start Date : May 2010
Primary Completion Date : April 2015
Study Completion Date : December 2015

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Healthy females aged >=18
Healthy female volunteers of skin type I or II

Primary Outcome Measures :
  1. Assessment of age related gene expression changes in skin [ Time Frame: Cross sectional ]

Biospecimen Retention:   Samples With DNA
Blood and skin samples

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy females age 18 or older

Inclusion Criteria:

  • healthy female, age 18 or older,
  • Fitzpatrick type 1 or 2 skin,
  • able to read and understand written consent form,
  • body mass index normal or overweight range,
  • willing to take blood tests and donate skin samples

Exclusion Criteria:

  • pregnant or lactating,
  • history of cosmetic surgery affecting the face,
  • use of prescription anti-aging medications for 2 weeks prior to study,
  • use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,
  • medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01451476

United States, California
Stanford Dermatology
Redwood City, California, United States, 94603
Sponsors and Collaborators
Stanford University
Principal Investigator: Alfred Lane, MD Stanford University
Study Director: Anne Chang, MD Stanford University

Responsible Party: Anne Chang, instructor, Stanford University Identifier: NCT01451476     History of Changes
Other Study ID Numbers: HSA_GEP
003 ( Other Grant/Funding Number: NuSkin International )
First Posted: October 13, 2011    Key Record Dates
Last Update Posted: April 19, 2016
Last Verified: April 2016

Keywords provided by Anne Chang, Stanford University: