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Human Skin Aging: Clinical Parameters and Gene Expression Profiling (GEP)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01451476
First Posted: October 13, 2011
Last Update Posted: April 19, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Anne Chang, Stanford University
  Purpose
Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.

Condition
Ageing

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Human Skin Aging: Clinical Parameters and Gene Expression Profiling

Resource links provided by NLM:


Further study details as provided by Anne Chang, Stanford University:

Primary Outcome Measures:
  • Assessment of age related gene expression changes in skin [ Time Frame: Cross sectional ]

Biospecimen Retention:   Samples With DNA
Blood and skin samples

Enrollment: 122
Study Start Date: May 2010
Study Completion Date: December 2015
Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts
Healthy females aged >=18
Healthy female volunteers of skin type I or II

Detailed Description:
This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy females age 18 or older
Criteria

Inclusion Criteria:

  • healthy female, age 18 or older,
  • Fitzpatrick type 1 or 2 skin,
  • able to read and understand written consent form,
  • body mass index normal or overweight range,
  • willing to take blood tests and donate skin samples

Exclusion Criteria:

  • pregnant or lactating,
  • history of cosmetic surgery affecting the face,
  • use of prescription anti-aging medications for 2 weeks prior to study,
  • use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,
  • medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01451476


Locations
United States, California
Stanford Dermatology
Redwood City, California, United States, 94603
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Alfred Lane, MD Stanford University
Study Director: Anne Chang, MD Stanford University
  More Information

Responsible Party: Anne Chang, instructor, Stanford University
ClinicalTrials.gov Identifier: NCT01451476     History of Changes
Other Study ID Numbers: HSA_GEP
003 ( Other Grant/Funding Number: NuSkin International )
First Submitted: October 11, 2011
First Posted: October 13, 2011
Last Update Posted: April 19, 2016
Last Verified: April 2016

Keywords provided by Anne Chang, Stanford University:
Ageing