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Human Skin Aging: Clinical Parameters and Gene Expression Profiling (GEP)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Anne Chang, Stanford University
ClinicalTrials.gov Identifier:
NCT01451476
First received: October 11, 2011
Last updated: April 18, 2016
Last verified: April 2016
  Purpose
Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.

Condition
Ageing

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Human Skin Aging: Clinical Parameters and Gene Expression Profiling

Resource links provided by NLM:


Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Assessment of age related gene expression changes in skin [ Time Frame: Cross sectional ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA
Blood and skin samples

Enrollment: 122
Study Start Date: May 2010
Study Completion Date: December 2015
Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts
Healthy females aged >=18
Healthy female volunteers of skin type I or II

Detailed Description:
This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.
  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy females age 18 or older
Criteria

Inclusion Criteria:

  • healthy female, age 18 or older,
  • Fitzpatrick type 1 or 2 skin,
  • able to read and understand written consent form,
  • body mass index normal or overweight range,
  • willing to take blood tests and donate skin samples

Exclusion Criteria:

  • pregnant or lactating,
  • history of cosmetic surgery affecting the face,
  • use of prescription anti-aging medications for 2 weeks prior to study,
  • use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,
  • medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01451476

Locations
United States, California
Stanford Dermatology
Redwood City, California, United States, 94603
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Alfred Lane, MD Stanford University
Study Director: Anne Chang, MD Stanford University
  More Information

Responsible Party: Anne Chang, instructor, Stanford University
ClinicalTrials.gov Identifier: NCT01451476     History of Changes
Other Study ID Numbers: HSA_GEP  003 
Study First Received: October 11, 2011
Last Updated: April 18, 2016
Health Authority: United States: Institutional Review Board

Keywords provided by Stanford University:
Ageing

ClinicalTrials.gov processed this record on December 07, 2016