Sleep, Circadian Rhythms and Cluster Headache
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|ClinicalTrials.gov Identifier: NCT01447641|
Recruitment Status : Completed
First Posted : October 6, 2011
Last Update Posted : April 13, 2017
The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache. For sufferers with the episodic form of the disorder this will involve observation at two separate time points, once when experiencing attacks (in-bout) and once when attack free (out-of-bout).
The study will include measurement of basic rest-activity patterns, sleep timing and timing of individual attacks, as well as a more detailed study recording sleep and circadian rhythms under clinical conditions over consecutive nights.
Studying the differences in these processes in single individuals when they are both experiencing and free from attacks might provide insight into the brain mechanisms involved in triggering the bouts of attacks and individual attacks themselves. An improved understanding of this area may help design improved treatment options in future.
|Condition or disease||Intervention/treatment|
|Cluster Headache||Other: Polysomnography Other: Actigraphy|
|Study Type :||Observational|
|Actual Enrollment :||8 participants|
|Official Title:||Characterisation of Sleep and Circadian Physiology in Individuals With Cluster Headache|
|Study Start Date :||August 2011|
|Actual Primary Completion Date :||April 2017|
|Actual Study Completion Date :||April 2017|
Cluster headache sufferers (both chronic and episodic)
Overnight physiological recording of sleepOther: Actigraphy
Wristwatch activity to measure basic rest activity cycle and sleep efficiency
- amplitude and phase of circadian rhythm of melatonin [ Time Frame: 36 hours ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01447641
|Surrey Clinical Research Centre, University of Surrey|
|Guildford, United Kingdom, GU2 7XP|
|Principal Investigator:||Alexander D Nesbitt, BM BCh MRCP||University of Surrey|