A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior (IPT-A-CSP)
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ClinicalTrials.gov Identifier: NCT01447602 |
Recruitment Status
:
Completed
First Posted
: October 6, 2011
Last Update Posted
: September 4, 2014
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Unipolar Depression Dysthymia | Behavioral: IPT-A | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 10 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | An Open Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior |
Study Start Date : | September 2011 |
Actual Primary Completion Date : | June 2014 |
Actual Study Completion Date : | June 2014 |

Arm | Intervention/treatment |
---|---|
Experimental: Interpersonal psychotherapy (IPT-A)
Interpersonal psychotherapy for depressed adolescents which focuses on identifying problematic relationships connected to onset or maintenance of depression and suicidal behavior. The treatment teaches skills such as communication and problem-solving to the adolescent and parents.
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Behavioral: IPT-A
Interpersonal Psychotherapy for adolescents (IPT-A) is a guideline based treatment with established efficacy as an intervention for adolescent depression
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- Score on Columbia Suicide Severity Rating Scale (C-SSRS) [ Time Frame: Up to 42 weeks ]The C-SSRS is a scale that assesses for the presence of suicidal behavior.
- Change in score on Children's Depression Rating Scale (CDRS) [ Time Frame: Week 20 and 3 month follow-up ]The CDRS is a clinician rated instrument that assesses for the presence and severity of depressive symptoms.

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Ages Eligible for Study: | 12 Years to 19 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Males and females ages 12-19 years
- English speaking adolescent
- Parent may be monolingual or bilingual in Spanish
- DSM-IV diagnosis of MDD, dysthymia, DDNOS
- Moderate impairment in functioning
- Moderate to severe depression severity
- Expressed risk for suicide or reported non-medically lethal attempt. Non-lethal attempt is defined as an attempt that did not require medical hospitalization but may require psychiatric hospitalization which often includes being in the Emergency Room for several days because there was no bed available.
Exclusion Criteria:
- Suicide attempt in the past 4 months with medical lethality that requires hospitalization which often includes being in the ER for several days because there was no bed available.
- Severe impairment in functioning
- Diagnoses of Substance abuse, Schizophrenia, bipolar disorder,Conduct disorder, primary eating disorder, Psychosis, obsessive-compulsive disorder,
- Engagement in self-injurious that requires medical treatment in the past month
- Mental retardation or severe learning disability
- Medical illness that may interfere with treatment
- Current physical or sexual abuse
- Open Administration for Children's Services (ACS) case
- Pregnancy
- Already receiving treatment for depression or have begun a medication trial for another diagnosis within the previous three months

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01447602
United States, New York | |
New York Presbyterian Hospital | |
New York, New York, United States, 10032 | |
New York State Psychiatric Institute | |
New York, New York, United States, 10032 |
Principal Investigator: | Laura Mufson, PhD | New York State Psychiatric Institute |
Responsible Party: | New York State Psychiatric Institute |
ClinicalTrials.gov Identifier: | NCT01447602 History of Changes |
Other Study ID Numbers: |
6238 |
First Posted: | October 6, 2011 Key Record Dates |
Last Update Posted: | September 4, 2014 |
Last Verified: | April 2013 |
Keywords provided by New York State Psychiatric Institute:
Major Depressive Disorder (MDD) Dysthymia Depressive Disorder Not Otherwise Specified (DDNOS) |
Additional relevant MeSH terms:
Suicide Depressive Disorder Dysthymic Disorder Self-Injurious Behavior |
Behavioral Symptoms Mood Disorders Mental Disorders |