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Phenotypic Expressions in a French Pseudoxanthoma-Elasticum Cohort

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ClinicalTrials.gov Identifier: NCT01446380
Recruitment Status : Recruiting
First Posted : October 5, 2011
Last Update Posted : October 5, 2011
Information provided by (Responsible Party):
University Hospital, Angers

Brief Summary:
The cohort is intended to study the phenotypic expressions of the pseudoxanthoma elasticum (PXE) disease in various tissues (eye, skin, arteries, etc).

Condition or disease
Pseudoxanthoma Elasticum

Detailed Description:

This national french cohort is intended to improve our knowledge on the PXE disease. The study of phenotypic expression of the diseases is focused on cutaneous, opthalmologic and vascular tissues. All investigations are included in a yearly follow-up for these patients and collected in a database.

Plasma are also collected for all patients and stored in our clinical research biological center in Angers, including genetic (DNA) material extracted from diagnostic skin biopsy. French Ministry of Teaching and Research Authorisation number for the PXE collection is AC 2008 871. Declarative number is DC 2008 870.

Study Type : Observational
Estimated Enrollment : 350 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Phenotypic Expressions in a French Pseudoxanthoma-Elasticum Cohort
Study Start Date : June 2008
Estimated Primary Completion Date : January 2020
Estimated Study Completion Date : January 2021

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Pseudoxanthoma elasticum

Biospecimen Retention:   Samples With DNA
Sera,Plasma,DNA,skin biopsy

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients diagnosed for a PXE disease from any part of France and requesting a follow-up and clinical management of there disease (opthalmic and vascular complications mainly).

Inclusion Criteria:

  • Patients with PXE disease
  • Informed consent obtained
  • Patient affiliated to Health care system (french social security)

Exclusion Criteria:

  • No informed consent
  • No affiliation to a Health care system

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01446380

Contact: Ludovic MARTIN, MD PhD 33(2)41-35-34-19 LuMartin@chu-angers.fr
Contact: Georges LEFTHERIOTIS, MD-PHD 33(2)41-35-44-56 GeLeftheriotis@chu-angers.fr

University Hospital of Angers Recruiting
Angers, Pays de Loire, France, 49933
Contact: Ludovic MARTIN, MD-PhD    33(0)2-41-35-34-19    LuMartin@chu-angers.fr   
Contact: Georges LEFTHERIOTIS, MD-PhD    33(0)2-41-35-44-56    GeLeftheriotis@chu-angers.fr   
Sub-Investigator: Georges LEFTHERIOTIS, MD-PHD         
Sub-Investigator: Pierre ABRAHAM, MD-PHD         
Sub-Investigator: Fabrice PRUNIER, MD-PHD         
Sub-Investigator: Jean Marc EBRAN, MD         
Sponsors and Collaborators
University Hospital, Angers
Study Director: Ludovic MARTIN, MD PhD UH Angers

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: University Hospital, Angers
ClinicalTrials.gov Identifier: NCT01446380     History of Changes
Other Study ID Numbers: AC 2008 871
First Posted: October 5, 2011    Key Record Dates
Last Update Posted: October 5, 2011
Last Verified: October 2009

Additional relevant MeSH terms:
Pseudoxanthoma Elasticum
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Hemorrhagic Disorders
Hematologic Diseases
Skin Abnormalities
Congenital Abnormalities
Skin Diseases, Genetic
Genetic Diseases, Inborn
Connective Tissue Diseases
Skin Diseases