Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart
Recruitment status was: Not yet recruiting
Right-sided heart disease has an important impact on the prognosis of patients with valvular heart disease. Up to now, Tricuspid Valve Regurgitation (TR) and right heart hemodynamics have not been extensively investigated. However, it is plausible that a significant degree of TR and the associated volume-overload of the right ventricle cause significant right ventricular wall stress. Although minor TR generally is well tolerated, major TR can lead to clinical symptoms, right ventricular dilatation and ultimately right ventricular heart failure. Up to now, the investigators do not dispose of any tools to diagnose and anticipate this unfavourable evolution. Nevertheless it is likely that right ventricular failure is preceded with a subclinical dysfunction of the right ventricle and a possibly reversible change in contractility of the myocardium.
Recently, new techniques to evaluate the systolic function, the contractility and the hemodynamics of the heart have become available.
First, this study will help us assessing the feasibility and accuracy of several imaging modalities in right-sided heart pathology with focus on TR and right heart myocardial performance.
Second, this study will contribute to a better understanding of the hemodynamic effect of volume-overload and/or pressure-overload of the right ventricle. It will clarify the behaviour of TR, the evolution of right ventricular myocardial contractility and dysfunction during exercise and its impact on exercise capacity. By doing this, discrimination between well tolerated and ill-tolerated TR will be possible, thus identifying patients who might be eligible for treatment (medical, corrective, …).
|Tricuspid Valve Insufficiency|
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart|
|Study Start Date:||October 2011|
|Estimated Study Completion Date:||August 2012|
|pulmonic valve stenosis|
|pulmonic valve homograft|
|pulmonic valve insufficiency|
|atrial septum defect|
|transvalvular right ventricular lead|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01444222
|Contact: Pieter De Meester, MD||016342371 ext firstname.lastname@example.org|
|UZLeuven||Not yet recruiting|
|Leuven, Vlaams-Brabant, Belgium, 3000|
|Contact: Pieter De Meester, MD 016342371 ext 0032 email@example.com|
|Principal Investigator:||Werner Budts, MD, PhD||Universitaire Ziekenhuizen Leuven|