Graft Rejection or Tolerance Affected by Serial Change of Anti-donor Lymphocyte Antibody After Liver Transplantation
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|ClinicalTrials.gov Identifier: NCT01444079|
Recruitment Status : Completed
First Posted : September 30, 2011
Last Update Posted : January 27, 2015
Liver is an organ that is well-known for its immune tolerant capacity. However, there were still controversial issues about the impact of immunologic challenge after liver transplantation on the graft function. Different results of graft function affected by immunologic factors such as pre-transplant panel reactive antibody (PRA) status, pre-transplant positive lymphocyte cross match (LCM), or post-transplant circulating donor specific antibody (DSA) has been reported according to individual institutes. There was no trial for presenting anti-donor lymphocyte antibody change after liver transplantation.
The investigators designed this study to analyze the correlation between pre- and post-transplant immune status (PRA, LCM), and graft survival / rejection episode. Also, the investigators will find aspects of anti-donor lymphocyte antibody change after liver transplantation.
|Condition or disease|
|Liver Transplant Rejection|
|Study Type :||Observational|
|Actual Enrollment :||48 participants|
|Official Title:||Graft Rejection or Tolerance Affected by Serial Change of Anti-donor Lymphocyte Antibody After Liver Transplantation|
|Study Start Date :||April 2011|
|Actual Primary Completion Date :||February 2014|
|Actual Study Completion Date :||February 2014|
Liver transplant recipients
Recipients who will undergo liver transplantation during study period
- incidence of acute rejection [ Time Frame: Time point when patients are diagnosed acute rejection ]We designed to analyze the aspects of acute rejection between anti-donor lymphocyte antibody change liver transplantation.
- correlation between pre- and post-transplant immune status (PRA, LCM), and graft survival [ Time Frame: at 7 day, 14 day, 21 day after transplantation and at 3 month, 6 month after transplantation ]We designed this study to analyze the correlation between pre- and post-transplant immune status (PRA, LCM), and graft survival / rejection episode.
Biospecimen Retention: None Retained
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01444079
|Korea, Republic of|
|Seoul, Korea, Republic of, 120-752|
|Principal Investigator:||Myoung Soo Kim, M.D.||Yonsei University College of Meidicine|