Characterisation of the Human Carboxylesterase 1 (CES1) Mutations in Thailand
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ClinicalTrials.gov Identifier: NCT01443806
Recruitment Status :
First Posted : September 30, 2011
Last Update Posted : June 27, 2018
University of Oxford
South East Asia Infectious Disease Clinical Research Network
The aim of this study is to evaluate the conversion of OP to OC in individual X and the family member of individual X. The investigators hypothesize that one or more of the single nucleoprotein polymorphisms (SNPs) of the CES1 gene represent a clinically important functional polymorphism.
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Layout table for eligibility information
Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Signed informed consent
Healthy family member of individual X and individual X
Aged between 18 and 70, inclusive.
known allergy to oseltamivir
any underlying illness that is considered a risk to the health of the individual
creatinine clearance < 30 mL/min calculated by the Cockcroft Gault formula: CrCl (ml/min) = (140-age) x Wt in kg / creatinine mg/dL x 72, for females, the result is multiplied by 0.85.