High MAP in Septic Shock With Hypertension
|Study Design:||Intervention Model: Single Group Assignment
Masking: No masking
Primary Purpose: Treatment
|Official Title:||High Mean Arterial Pressure Target Improves Microcirculation in Septic Shock Patients With Previous Hypertension|
- Mean Arterial Pressure [ Time Frame: Target MAP stabilization for 30 min ]
As chronic hypertensive patients were supposed to have undergone more blood pressure measurements in daily life than non-hypertensive ones, the averaged MAP acquired from patients' physical examination records of the last two years was registered and assumed as patients' usual level of MAP and target MAP. If patients' medical records were incomplete, a detailed enquiry about the target MAP to their next kin was performed.
After stabilization for 30 min, basal measurements including hemodynamic and microcirculatory measurements were taken, 20 min apart, the NE doses were increased to titrate MAP to the target level. Patients were allowed to stabilize for 30 min before taking new measurements.
- Perfused Vessel Density [ Time Frame: Target MAP stabilization for 30 min ]Increasing MAP from 65 mm Hg to target level. The sublingual microcirculation was measured by sidestream dark field, including the parameters of perfused vessel density
|Study Start Date:||June 2011|
|Study Completion Date:||June 2012|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
Experimental: NE group
Adjust NE dose to titrate MAP to usual level regardless of fluid responsiveness when after EGDT.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01443494
|Zhongda Hospital Southeast University|
|Nanjing, Jiangsu, China, 210000|
|Study Director:||Haibo Qiu, MD,PhD||Southeast University|