Demographic, Clinical, Laboratory and Genetical Characteristics of Patients With Beta Thalassemia Intermedia
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
- The characteristics of patients with thalassemia intermedia [ Time Frame: One year ] [ Designated as safety issue: No ]Observational study that analyzed the characteristics of thalassemia intermedia patients
Biospecimen Retention: Samples With DNA
|Study Start Date:||October 2011|
|Study Completion Date:||December 2014|
|Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Thalassemia Intermedia Patients
Patients with Beta Thalassemia Intermedia treated at the Pediatric Hematology Unit. The characterization of Thalassemia Intermedia was based on age at diagnosis (Older than 2 ys) and / or clinical characteristics that are milder than Thalassemia Major in patients homozygous for beta globin genes.
Genetic: Laboratory analysis.
The blood transfusions given to the patients are in accord to physician decision and not related to the study
The characteristics that will be recorded from the medical files include: demographic data, included gender and ethnic origin, family history, age at diagnosis, number and frequency of blood transfusions including age of first transfusion and physical examination findings.
The laboratory data included iron metabolism parameters, mutation in the alfa and beta gene and the presence of the xmn1 polymorphism.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01443312
|Pediatric Hematology Unit - Ha'Emek Medical Center|
|Afula, Israel, 18101|
|Principal Investigator:||Ariel Koren, MD||Ha'Emek Medical Center, Afula, Israel|