Desflurane Versus Propofol in the Sitting Position
|
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
| ClinicalTrials.gov Identifier: NCT01436799 |
|
Recruitment Status :
Completed
First Posted : September 20, 2011
Results First Posted : August 26, 2013
Last Update Posted : September 9, 2013
|
Sponsor:
Gachon University Gil Medical Center
Information provided by (Responsible Party):
Hyun Jeong Kwak, Gachon University Gil Medical Center
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
Brief Summary:
The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Cerebral Ischemia | Drug: propofol Drug: Desflurane Drug: alfentanil Drug: Rocuronium | Not Applicable |
The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.
| Study Type : | Interventional (Clinical Trial) |
| Actual Enrollment : | 40 participants |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | Single (Investigator) |
| Primary Purpose: | Prevention |
| Official Title: | International Review Board of Gachon University Gil Hospital |
| Study Start Date : | March 2011 |
| Actual Primary Completion Date : | August 2011 |
| Actual Study Completion Date : | August 2011 |
Resource links provided by the National Library of Medicine
| Arm | Intervention/treatment |
|---|---|
|
Experimental: Desflurane
anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane
|
Drug: Desflurane
anaesthesia was maintained by desflurane 4-7vol%
Other Name: Des Drug: alfentanil administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf Drug: Rocuronium administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc |
|
Active Comparator: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model
|
Drug: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly. Drug: alfentanil administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf Drug: Rocuronium administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc |
Primary Outcome Measures :
- Regional Cerebral Oxygen Satuation (rSO2) [ Time Frame: 1, 3, 5, 7, and 9 min after the beach chair position ]definitive values of regional cerebral oxygen saturation(rSO2,%) values are described as mean (SD)
Information from the National Library of Medicine
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
| Ages Eligible for Study: | 20 Years to 65 Years (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Forty patients,
- ASA class I or II,
- undergoing shoulder arthroscopy
Exclusion Criteria:
- Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01436799
Sponsors and Collaborators
Gachon University Gil Medical Center
Investigators
| Study Director: | Hyun Jeong Kwak, MD.PhD | Gachon University Gil Medical Center |
| Responsible Party: | Hyun Jeong Kwak, Associate professor, Gachon University Gil Medical Center |
| ClinicalTrials.gov Identifier: | NCT01436799 History of Changes |
| Other Study ID Numbers: |
GIRBA2466 |
| First Posted: | September 20, 2011 Key Record Dates |
| Results First Posted: | August 26, 2013 |
| Last Update Posted: | September 9, 2013 |
| Last Verified: | August 2013 |
Keywords provided by Hyun Jeong Kwak, Gachon University Gil Medical Center:
|
propofol desflurane cerebrovascular circulation sitting |
Additional relevant MeSH terms:
|
Ischemia Brain Ischemia Cerebral Infarction Pathologic Processes Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain Infarction Stroke Anesthetics Propofol Desflurane |
Isoflurane Alfentanil Rocuronium Central Nervous System Depressants Physiological Effects of Drugs Hypnotics and Sedatives Anesthetics, Intravenous Anesthetics, General Neuromuscular Nondepolarizing Agents Neuromuscular Blocking Agents Neuromuscular Agents Peripheral Nervous System Agents Anesthetics, Inhalation Analgesics, Opioid Narcotics |