Desflurane Versus Propofol in the Sitting Position
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ClinicalTrials.gov Identifier: NCT01436799 |
Recruitment Status :
Completed
First Posted : September 20, 2011
Results First Posted : August 26, 2013
Last Update Posted : September 9, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Cerebral Ischemia | Drug: propofol Drug: Desflurane Drug: alfentanil Drug: Rocuronium | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 40 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Investigator) |
Primary Purpose: | Prevention |
Official Title: | International Review Board of Gachon University Gil Hospital |
Study Start Date : | March 2011 |
Actual Primary Completion Date : | August 2011 |
Actual Study Completion Date : | August 2011 |

Arm | Intervention/treatment |
---|---|
Experimental: Desflurane
anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane
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Drug: Desflurane
anaesthesia was maintained by desflurane 4-7vol%
Other Name: Des Drug: alfentanil administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf Drug: Rocuronium administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc |
Active Comparator: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model
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Drug: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly. Drug: alfentanil administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf Drug: Rocuronium administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc |
- Regional Cerebral Oxygen Satuation (rSO2) [ Time Frame: 1, 3, 5, 7, and 9 min after the beach chair position ]definitive values of regional cerebral oxygen saturation(rSO2,%) values are described as mean (SD)

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Ages Eligible for Study: | 20 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Forty patients,
- ASA class I or II,
- undergoing shoulder arthroscopy
Exclusion Criteria:
- Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01436799
Study Director: | Hyun Jeong Kwak, MD.PhD | Gachon University Gil Medical Center |
Responsible Party: | Hyun Jeong Kwak, Associate professor, Gachon University Gil Medical Center |
ClinicalTrials.gov Identifier: | NCT01436799 |
Other Study ID Numbers: |
GIRBA2466 |
First Posted: | September 20, 2011 Key Record Dates |
Results First Posted: | August 26, 2013 |
Last Update Posted: | September 9, 2013 |
Last Verified: | August 2013 |
propofol desflurane cerebrovascular circulation sitting |
Brain Ischemia Cerebral Infarction Ischemia Pathologic Processes Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain Infarction Stroke Infarction Necrosis Alfentanil |
Propofol Desflurane Rocuronium Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Anesthetics, Intravenous Anesthetics, General Anesthetics Neuromuscular Nondepolarizing Agents Neuromuscular Blocking Agents Neuromuscular Agents Peripheral Nervous System Agents Anesthetics, Inhalation Analgesics, Opioid |