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Desflurane Versus Propofol in the Sitting Position
This study has been completed.
Sponsor:
Gachon University Gil Medical Center
Information provided by (Responsible Party):
Hyun Jeong Kwak, Gachon University Gil Medical Center
ClinicalTrials.gov Identifier:
NCT01436799
First received: September 15, 2011
Last updated: August 25, 2013
Last verified: August 2013
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Purpose
The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.
| Condition | Intervention |
|---|---|
| Cerebral Ischemia | Drug: propofol Drug: Desflurane Drug: alfentanil Drug: Rocuronium |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single Blind (Investigator) Primary Purpose: Prevention |
| Official Title: | International Review Board of Gachon University Gil Hospital |
Resource links provided by NLM:
Further study details as provided by Hyun Jeong Kwak, Gachon University Gil Medical Center:
Primary Outcome Measures:
- Regional Cerebral Oxygen Satuation (rSO2) [ Time Frame: 1, 3, 5, 7, and 9 min after the beach chair position ]definitive values of regional cerebral oxygen saturation(rSO2,%) values are described as mean (SD)
| Enrollment: | 40 |
| Study Start Date: | March 2011 |
| Study Completion Date: | August 2011 |
| Primary Completion Date: | August 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Desflurane
anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane
|
Drug: Desflurane
anaesthesia was maintained by desflurane 4-7vol%
Other Name: Des
Drug: alfentanil
administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf
Drug: Rocuronium
administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc
|
|
Active Comparator: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model
|
Drug: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly.
Drug: alfentanil
administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf
Drug: Rocuronium
administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc
|
Detailed Description:
The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.
Eligibility| Ages Eligible for Study: | 20 Years to 65 Years (Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Forty patients,
- ASA class I or II,
- undergoing shoulder arthroscopy
Exclusion Criteria:
- Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01436799
Please refer to this study by its ClinicalTrials.gov identifier: NCT01436799
Sponsors and Collaborators
Gachon University Gil Medical Center
Investigators
| Study Director: | Hyun Jeong Kwak, MD.PhD | Gachon University Gil Medical Center |
More Information
| Responsible Party: | Hyun Jeong Kwak, Associate professor, Gachon University Gil Medical Center |
| ClinicalTrials.gov Identifier: | NCT01436799 History of Changes |
| Other Study ID Numbers: |
GIRBA2466 |
| Study First Received: | September 15, 2011 |
| Results First Received: | February 5, 2013 |
| Last Updated: | August 25, 2013 |
Keywords provided by Hyun Jeong Kwak, Gachon University Gil Medical Center:
|
propofol desflurane cerebrovascular circulation sitting |
Additional relevant MeSH terms:
|
Ischemia Brain Ischemia Cerebral Infarction Pathologic Processes Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain Infarction Stroke Anesthetics Propofol Desflurane |
Isoflurane Alfentanil Rocuronium Central Nervous System Depressants Physiological Effects of Drugs Hypnotics and Sedatives Anesthetics, Intravenous Anesthetics, General Anesthetics, Inhalation Neuromuscular Nondepolarizing Agents Neuromuscular Blocking Agents Neuromuscular Agents Peripheral Nervous System Agents Analgesics, Opioid Narcotics |
ClinicalTrials.gov processed this record on June 23, 2017