Respiratory Muscle Strength and Function in Healthy Kids
|ClinicalTrials.gov Identifier: NCT01436318|
Recruitment Status : Completed
First Posted : September 19, 2011
Last Update Posted : September 23, 2014
|Condition or disease|
|Respiratory Muscle Strength|
The goals of this study are to collect and evaluate respiratory muscle strength training (RMST) induced changes in ventilatory function in healthy children. Children will undergo one session of pulmonary function and strength testing to quantify rate of inspiratory and expiratory pressure development and to determine whether inspiratory and expiratory pressure correlate to maximal respiratory pressures and forced pulmonary function tests. Currently normal pressure-flow-timing responses are not well-characterized in healthy children. The purpose of this study is to help develop more efficient RMST exercise prescriptions for ill children on ventilators and with neuromuscular weakness.
Participants in the study will refrain from caffeine products and exercise on the day of respiratory testing. In conjunction with respiratory testing, baseline and exertional blood pressure, heart and respiratory rate, and pulse oximetry will be monitored. Participants will complete tidal flow-volume assessments and forced expiratory maneuvers according to the AMerican Thoracic Society guidelines. Participants will undergo 5 sets of 10 maximal-effort breaths against standardized resistances (one set each at 0, 5, 10, 15, and 20 cm H20). Following each set, subjects will rate the load magnitude and their feelings of breathing discomfort using a 0-10 visual analog scale. Participants will also perform maximal inspiratory and expiratory pressure maneuvers. All tests will be separated by at least 2-3 minutes of rest.
|Study Type :||Observational|
|Actual Enrollment :||7 participants|
|Observational Model:||Ecologic or Community|
|Official Title:||Respiratory Muscle Strength and Function in Healthy Children|
|Study Start Date :||April 2011|
|Actual Primary Completion Date :||August 2014|
|Actual Study Completion Date :||September 2014|
Children will undergo one session of pulmonary function and strength testing
- Pulmonary Function Testing [ Time Frame: Day 1 ]Subjects will complete tidal flow-volume assessments and forced expiratory maneuvers.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01436318
|United States, Florida|
|University of Florida|
|Gainesville, Florida, United States, 32610|
|Principal Investigator:||Barbara K Smith, PT, PhD||University of Florida|