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S8600-S9031-S9333-A, Study of DNA in Samples From Patients With Acute Myeloid Leukemia

This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Southwest Oncology Group Identifier:
First received: September 13, 2011
Last updated: April 14, 2016
Last verified: April 2016

RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients respond to treatment.

PURPOSE: This research trial studies DNA in samples from patients with acute myeloid leukemia.

Condition Intervention
Genetic: DNA methylation analysis
Genetic: gene expression analysis
Genetic: microarray analysis
Other: laboratory biomarker analysis
Other: medical chart review

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: S8600-S9031-S9333-A, Identification of Differentially Methylated Genomic Regions That Are Prognostically Significant in AML

Resource links provided by NLM:

Further study details as provided by Southwest Oncology Group:

Primary Outcome Measures:
  • Identification of DMRs associated with OS [ Time Frame: immediate ]
  • Development and evaluation of a prognostic score of OS based on DMRs identified [ Time Frame: immediate ]
  • Prognostic score able to group AML patients into risk groups [ Time Frame: immediate ]

Enrollment: 200
Study Start Date: October 2011
Study Completion Date: December 2015
Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Detailed Description:


  • To identify differentially methylated regions (DMRs) associated with overall survival (OS) of acute myeloid leukemia (AML) patients with normal cytogenetics.
  • To develop and evaluate in an independent validation set a prognostic score for OS based on the identified DMR.
  • To determine whether the prognostic score can group patients into risk groups based on OS.

OUTLINE: Archived blood or bone marrow samples are analyzed for DNA methylation alterations by CHARM array-based genome assay. Each patient's clinical data is also collected.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients enrolled on S8600, S9031 or S9333 who consented to use of specimens for future research


  • De novo acute myeloid leukemia (AML) patients with normal cytogenetics treated with curative therapy who survived at least 28 days after therapy started
  • Samples will be taken from the following studies: SWOG-8600, SWOG-9031, SWOG-9333, SWOG-9500, SWOG-S9918, SWOG-S0106, and SWOG-S0112

    • Blood or marrow specimens can be used


  • Not specified


  • See Disease Characteristics
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01434329

Sponsors and Collaborators
Southwest Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Min Fang, MD, PhD Fred Hutchinson Cancer Research Center
  More Information

Responsible Party: Southwest Oncology Group Identifier: NCT01434329     History of Changes
Other Study ID Numbers: S8600-S9031-S9333-A
S8600-S9031-S9333-A ( Other Identifier: SWOG )
U10CA032102 ( US NIH Grant/Contract Award Number )
Study First Received: September 13, 2011
Last Updated: April 14, 2016

Keywords provided by Southwest Oncology Group:
untreated adult acute myeloid leukemia

Additional relevant MeSH terms:
Leukemia, Myeloid, Acute
Neoplasms by Histologic Type
Leukemia, Myeloid processed this record on April 26, 2017