S8600-S9031-S9333-A, Study of DNA in Samples From Patients With Acute Myeloid Leukemia
|ClinicalTrials.gov Identifier: NCT01434329|
Recruitment Status : Completed
First Posted : September 14, 2011
Last Update Posted : April 15, 2016
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients respond to treatment.
PURPOSE: This research trial studies DNA in samples from patients with acute myeloid leukemia.
|Condition or disease||Intervention/treatment|
|Leukemia||Genetic: DNA methylation analysis Genetic: gene expression analysis Genetic: microarray analysis Other: laboratory biomarker analysis Other: medical chart review|
- To identify differentially methylated regions (DMRs) associated with overall survival (OS) of acute myeloid leukemia (AML) patients with normal cytogenetics.
- To develop and evaluate in an independent validation set a prognostic score for OS based on the identified DMR.
- To determine whether the prognostic score can group patients into risk groups based on OS.
OUTLINE: Archived blood or bone marrow samples are analyzed for DNA methylation alterations by CHARM array-based genome assay. Each patient's clinical data is also collected.
|Study Type :||Observational|
|Actual Enrollment :||200 participants|
|Official Title:||S8600-S9031-S9333-A, Identification of Differentially Methylated Genomic Regions That Are Prognostically Significant in AML|
|Study Start Date :||October 2011|
|Actual Primary Completion Date :||December 2015|
|Actual Study Completion Date :||December 2015|
- Identification of DMRs associated with OS [ Time Frame: immediate ]
- Development and evaluation of a prognostic score of OS based on DMRs identified [ Time Frame: immediate ]
- Prognostic score able to group AML patients into risk groups [ Time Frame: immediate ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01434329
|Principal Investigator:||Min Fang, MD, PhD||Fred Hutchinson Cancer Research Center|