Prediction of Mortality in Patients Waiting for Liver Transplantation Through Brain Magnetic Resonance Imaging
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|ClinicalTrials.gov Identifier: NCT01434056|
Recruitment Status : Unknown
Verified September 2011 by Ellison Fernando Cardoso, Hospital Israelita Albert Einstein.
Recruitment status was: Not yet recruiting
First Posted : September 14, 2011
Last Update Posted : September 14, 2011
|Condition or disease|
|End Stage Liver Disease Hepatic Encephalopathy|
The only current definitive treatment for end-stage liver disease is transplantation. Due to the scarcity of organs available, the correct prioritization of patients for liver transplantation has a crucial importance. Nowadays, patients are ranked according to severity of liver disease, measured by the MELD score. This index is only derived from objective measures (serum concentration of bilirubin, creatinine and INR). Hepatic encephalopathy (HE) is a serious and progressive disorder in patients with end-stage liver disease. The severity of HE has prognostic implications in those waiting for liver transplantation. However, the prognosis of HE is independent and not correlated to the MELD score. Hepatic encephalopathy triggers multiple changes in brain magnetic resonance imaging (MRI) providing an objective way to evaluate it. Also electroencephalogram and neuropsychological evaluation might increase mortality prediction.
Adding the information provided by MRI, electroencephalogram and neuropsychological evaluation to the MELD score model might increase the prediction of mortality. Increase mortality's prediction has a fundamental importance because in organ allocation.
We will evaluate the predictive value of these variables in predicting mortality of those patients waiting for liver transplantation.
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Official Title:||Prediction of Mortality in Patients Waiting for Liver Transplantation Through Brain Magnetic Resonance Imaging|
|Study Start Date :||November 2011|
|Estimated Primary Completion Date :||November 2014|
|Estimated Study Completion Date :||February 2015|
Liver transplantation waiting list
Patients waiting for liver transplantation with chronic end staged liver disease
- Mortality [ Time Frame: Three months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01434056
|Contact: Ellison F Cardoso, MD, PhDfirstname.lastname@example.org|
|Hospital Israelita Albert Einstein|
|São Paulo, Brazil, 05652901|
|Contact: Ellison F Cardoso, MD, PhD 551121512487 email@example.com|
|Principal Investigator: Ellison F Cardoso, MD, PhD|
|Study Chair:||Edson Amaro Junior, MD,PhD||Hospital Israelita Albert Einstein|