Cell Collection to Study Eye Diseases
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01432847|
Recruitment Status : Recruiting
First Posted : September 13, 2011
Last Update Posted : February 20, 2020
- Best Vitelliform Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye. Doctors cannot safely obtain retinal cells to study these diseases. However, cells collected from hair follicles, skin, and blood can be used for research. Researchers want to collect cells from people with Best disease, L-ORD, and AMD, and compare their cells with those of healthy volunteers.
- To collect hair, skin, and blood samples to study three eye diseases that affect the retina: Best disease, L-ORD, and AMD.
- Individuals affected with ocular condition is one year of age or older.
- Individuals affected with Best disease, L-ORD, or AMD is 18 years of age or older.
- Unaffected individuals are seven years of age or older.
- The study requires one visit to the National Eye Institute.
- Participants will be screened with a medical and eye disease history. They will also have an eye exam.
- Participants will provide a hair sample, a blood sample, and a skin biopsy. The hair will be collected from the back of the head, and the skin will be collected from the inside of the upper arm.
|Condition or disease|
|Retinal Disease AMD Retinal Degeneration Retinitis Pigmentosa|
|Study Type :||Observational|
|Estimated Enrollment :||930 participants|
|Official Title:||Generation of Induced Pluripotent Stem (iPS) Cell Lines From Somatic Cells of Participants With Eye Diseases and From Somatic Cells of Matched Controls|
|Actual Study Start Date :||September 7, 2011|
Participants affected by ocular diseases/conditions.
Age, gender, and ethnicity-matched to participants with ocular conditions.
- Creation of iPS cells from at least 1 type of somatic tissue collected from participants, differentiation of iPS cells into RPE and/or neural retinal The creation of iPS cells from at least one type of somatic tissue collected from participants. [ Time Frame: Ongoing ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01432847
|Contact: Allison T Bamji, R.N.||(301) firstname.lastname@example.org|
|Contact: Robert B Hufnagel, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Robert B Hufnagel, M.D.||National Eye Institute (NEI)|