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Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings

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ClinicalTrials.gov Identifier: NCT01430897
Recruitment Status : Completed
First Posted : September 8, 2011
Last Update Posted : September 8, 2011
Sponsor:
Information provided by (Responsible Party):
Matthias Grothoff, M.D., University of Leipzig

Brief Summary:

Systemic RV hypertrophy and impaired systolic function occur after atrial switch (AS) in d-transposition of the great arteries (d-TGA). Echocardiography has limitation in the assessment of the right ventricle (RV).

In this study the investigators sought to evaluate systemic RV myocardial mass and function after AS for d-TGA and to analyze the role of excessive hypertrophy for ventricular function under special consideration of the interventricular septal (IVS) movement.


Condition or disease
Right Ventricular Hypertrophy d-TGA

Study Type : Observational
Actual Enrollment : 37 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Right Ventricular Hypertrophy After Atrial Switch Operation and Its Role in a Systemic RV: Normal Adaptation Process or Risk Factor? A Cardiovascular Magnetic Resonance Study
Study Start Date : April 2007
Primary Completion Date : April 2011
Study Completion Date : September 2011

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Thirty-seven consecutive patients who came to regular outpatient visits at our tertiary care institution were referred to CMR.

Patient parameters were compared to a control group of 25 healthy age matched volunteers.

Criteria

Inclusion Criteria:

  • Eligibility criteria were an AS operation in childhood for correction of d-TGA and the absence of associated hemodynamically significant heart defects.

Exclusion Criteria:

  • Exclusion criteria were usual CMR contraindications such as ferromagnetic metallic implants.

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01430897


Locations
Germany
University of Leipzig - Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
Investigators
Study Chair: Matthias Gutberlet, MD University pf Leipzig - Heart Center

Publications:
Responsible Party: Matthias Grothoff, M.D., Consultant Radiology, University of Leipzig
ClinicalTrials.gov Identifier: NCT01430897     History of Changes
Other Study ID Numbers: 261-11-22082011
First Posted: September 8, 2011    Key Record Dates
Last Update Posted: September 8, 2011
Last Verified: September 2011

Keywords provided by Matthias Grothoff, M.D., University of Leipzig:
d-TGA
dextro Transposition of the great arteries
systemic right ventricle
right ventricular failure
Atrial switch procedure

Additional relevant MeSH terms:
Hypertrophy
Hypertrophy, Right Ventricular
Pathological Conditions, Anatomical
Cardiomegaly
Heart Diseases
Cardiovascular Diseases