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Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings

This study has been completed.
Information provided by (Responsible Party):
Matthias Grothoff, M.D., University of Leipzig Identifier:
First received: September 5, 2011
Last updated: September 7, 2011
Last verified: September 2011

Systemic RV hypertrophy and impaired systolic function occur after atrial switch (AS) in d-transposition of the great arteries (d-TGA). Echocardiography has limitation in the assessment of the right ventricle (RV).

In this study the investigators sought to evaluate systemic RV myocardial mass and function after AS for d-TGA and to analyze the role of excessive hypertrophy for ventricular function under special consideration of the interventricular septal (IVS) movement.

Right Ventricular Hypertrophy d-TGA

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Right Ventricular Hypertrophy After Atrial Switch Operation and Its Role in a Systemic RV: Normal Adaptation Process or Risk Factor? A Cardiovascular Magnetic Resonance Study

Resource links provided by NLM:

Further study details as provided by Matthias Grothoff, M.D., University of Leipzig:

Enrollment: 37
Study Start Date: April 2007
Study Completion Date: September 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Thirty-seven consecutive patients who came to regular outpatient visits at our tertiary care institution were referred to CMR.

Patient parameters were compared to a control group of 25 healthy age matched volunteers.


Inclusion Criteria:

  • Eligibility criteria were an AS operation in childhood for correction of d-TGA and the absence of associated hemodynamically significant heart defects.

Exclusion Criteria:

  • Exclusion criteria were usual CMR contraindications such as ferromagnetic metallic implants.
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Please refer to this study by its identifier: NCT01430897

University of Leipzig - Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
Study Chair: Matthias Gutberlet, MD University pf Leipzig - Heart Center
  More Information

Responsible Party: Matthias Grothoff, M.D., Consultant Radiology, University of Leipzig Identifier: NCT01430897     History of Changes
Other Study ID Numbers: 261-11-22082011
Study First Received: September 5, 2011
Last Updated: September 7, 2011

Keywords provided by Matthias Grothoff, M.D., University of Leipzig:
dextro Transposition of the great arteries
systemic right ventricle
right ventricular failure
Atrial switch procedure

Additional relevant MeSH terms:
Hypertrophy, Right Ventricular
Pathological Conditions, Anatomical
Heart Diseases
Cardiovascular Diseases processed this record on August 18, 2017