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Endometrial Priming for Embryo Transfer

This study has been completed.
Information provided by (Responsible Party):
Parc de Salut Mar Identifier:
First received: June 20, 2011
Last updated: November 2, 2015
Last verified: November 2015

The aim of this trial is compare two different endometrial priming protocols

  • women that receive oral estrogens
  • women that receive transdermal estrogens

Condition Intervention Phase
Drug: Oral strogen
Drug: Transdermal strogen
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Randomised Control Trial to Evaluate Efficacy and Safety of Two Different Protocols of Endometrial Priming for Embryo Transfer.

Further study details as provided by Parc de Salut Mar:

Primary Outcome Measures:
  • Difference between day means in endometrial priming to achieve 7 mm. [ Time Frame: 11-16 days ]

Secondary Outcome Measures:
  • Biochemical Pregnancy rate [ Time Frame: 26-30 days ]
    To calculate the biochemical pregnancy rate, we will divide the number of biochemical pregnancy into the number of embryonary transference and multiply by 100.

  • The patient's adherence to the recommended treatment. [ Time Frame: 1-16 days ]

Enrollment: 140
Study Start Date: July 2010
Study Completion Date: July 2015
Primary Completion Date: October 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Oral strogen Drug: Oral strogen
2 mg of estradiol every day beginning the second day of the cycle until day 7. 4 mg of estradiol every day beginning 8th day of the cycle until day 10. 6 mg of estradiol every day beginning 11th day of the cycle until day 16.
Experimental: Transdermal strogen Drug: Transdermal strogen
One patch of 75 mcg of estradiol hemimydrate every 48 h from 2 to day 6. Two patches of 75 mcg of estradiol hemimydrate every 48 h from 6 to day 12. Three patches of 75 mcg of estradiol hemimydrate every 48 h from 12 to day 16.


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Women between 18-50 years old with desire of children and needs of embryo transfer.
  • Plasma prolactin less than 30.
  • Uterine cavity that allow pregnancy, body mass index between 20-30.
  • And signed consent inform.

Exclusion Criteria:

  • History of estrogen dependent cancer, unknown origin vaginal bleeding.
  • Ovarian cyst.
  • Contraindications to be pregnant.
  • Estrogen allergy.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01430650

Hospital del Mar
Barcelona, Spain, 08003
Sponsors and Collaborators
Parc de Salut Mar
  More Information

Responsible Party: Parc de Salut Mar Identifier: NCT01430650     History of Changes
Other Study ID Numbers: UREP-PREPENDO-2010
Study First Received: June 20, 2011
Last Updated: November 2, 2015

Keywords provided by Parc de Salut Mar:
Oral estrogens
transdermal estrogens
endometrial priming

Additional relevant MeSH terms:
Genital Diseases, Male
Genital Diseases, Female
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Androgen Antagonists
Hormone Antagonists
Estrogen Antagonists processed this record on May 25, 2017