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Prognostic Relevance of High-sensitivity Troponin in Patients With Acute Decompensated Heart Failure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01429857
First Posted: September 7, 2011
Last Update Posted: June 14, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Christian Ukena, University Hospital, Saarland
  Purpose
The purpose of this study is to investigate the prognostic value of admission high-sensitivity troponin in patients with acute decompensated heart failure.

Condition
Heart Failure

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prognostic Relevance of High-sensitivity Troponin in Patients With Acute Decompensated Heart Failure

Resource links provided by NLM:


Further study details as provided by Christian Ukena, University Hospital, Saarland:

Primary Outcome Measures:
  • Time to cardiovascular death or hospitalization [ Time Frame: 6 Months Follow-Up ]

Secondary Outcome Measures:
  • Time to all cause death or hospitalization [ Time Frame: 6 Months Follow-Up ]

Enrollment: 304
Study Start Date: June 2010
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Detailed Description:
Patients admitted for acute decompensated heart failure are included in the study. After gaining informed consent, concentrations of high-sensitivity troponin on admission and on discharge are assessed. 6 months after discharged, the incidence of clinical endpoint (mortality of all cause and of cardiovascular cause, hospitalization) is assessed by telephone contact to the patient and/or the physician. The aim of the study is to investigate the prognostic value of high-sensitivity troponin concentration for predicting death and re-hospitalization.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Primary care clinic
Criteria

Inclusion Criteria:

  • Hospital admission for acute cardiac decompensation
  • Systolic and / or diastolic heart failure

Exclusion Criteria:

  • Myocardial infarction in the last 4 weeks
  • Serum creatinine >2.5 mg/dl
  • Pulmonary embolism
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01429857


Locations
Germany
Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivtherapie
Homburg, Saarland, Germany, 66421
Sponsors and Collaborators
University Hospital, Saarland
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Christian Ukena, Dr. med. Christian Ukena, University Hospital, Saarland
ClinicalTrials.gov Identifier: NCT01429857     History of Changes
Other Study ID Numbers: Hom-AHF-Troponin
First Submitted: February 1, 2011
First Posted: September 7, 2011
Last Update Posted: June 14, 2013
Last Verified: June 2013

Keywords provided by Christian Ukena, University Hospital, Saarland:
Troponin concentration in heart failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases