Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
|ClinicalTrials.gov Identifier: NCT01427621|
Recruitment Status : Completed
First Posted : September 1, 2011
Last Update Posted : September 1, 2011
|Condition or disease||Intervention/treatment||Phase|
|Heart Valve Diseases||Procedure: remote ischemic pre and postconditioning (RIPC)||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||54 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Official Title:||Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery|
|Study Start Date :||March 2010|
|Actual Primary Completion Date :||November 2010|
|Actual Study Completion Date :||May 2011|
|Experimental: RIPCcom group||
Procedure: remote ischemic pre and postconditioning (RIPC)
RIPCcom group: combined intervention of remote ischemic pre- and postconditioning consisted of three 10-minute cycles of right lower limb ischemia, which was induced with an automated cuff-inflator placed on the right upper leg and inflated to 250 mmHg, with an intervening 10 minute of reperfusion during which the cuff was deflated. This intervention were performed at 10 minutes after induction of anesthesia and then 10 min after weaning from CPB.
Other Name: combined intervention of remote ischemic preconditioning and remote ischemic postconditioning.
|No Intervention: Control group|
- Comparison of postoperative PaO2/FiO2 [ Time Frame: at 10 minutes after anesthetic induction ]Comparison of postoperative PaO2/FiO2 between RIPCcom group and Control group.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01427621
|Principal Investigator:||Young-Lan Kwak, MD, Ph.D||Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine|