Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly
|ClinicalTrials.gov Identifier: NCT01427231|
Recruitment Status : Completed
First Posted : September 1, 2011
Last Update Posted : March 21, 2012
|Condition or disease||Intervention/treatment|
|Mental Health Cognition Memory Attention||Dietary Supplement: glucose Dietary Supplement: sacharose Dietary Supplement: Placebo|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||43 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||The Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly Subjects|
|Study Start Date :||August 2011|
|Primary Completion Date :||December 2011|
|Study Completion Date :||December 2011|
Active Comparator: Drink with 50 g glucose
The glucose drink contains 50 g of glucose soluted in 250 ml of water and lemon juice.
Dietary Supplement: glucose
The effect of a glucose solution on cognitive performance will be measured.
Other Name: Sucrose, sugar.
Active Comparator: Drink with 100 gram of sacharose
The sacharose drink contains 100 g of sacharose soluted in 250 ml of water and lemon juice.
Dietary Supplement: sacharose
The effect of a sacharose solution on cognitive performance will be measured.
Placebo Comparator: Placebo with sweeteners
The placebo contains a mixture of artificial sweeteners in order to have the same sweetness and appearance of the test drinks (the glucose drink and the sacharose drink).
Dietary Supplement: Placebo
The effect of a placebo drink with sweeteners on cognitive performance will be measured.
- Performance on the paired associate recall test [ Time Frame: cognitive tests will start 15 minutes after ingestion of the intervention product ]Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed
- Mood [ Time Frame: within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink) ]Mood will be measured by the POMS, after consuming the test drink, and after completing the congitive tests.
- Blood glucose response [ Time Frame: from baseline till 90 minutes after consuming the drink ]Blood glucose will be measured at five time points, at t=0, after 15 minutes, 30, 60 and 90 minutes.
- Plasma insulin levels [ Time Frame: At t= -15 minutes, before consuming the test drink ]One venapunction will be carried out at baseline to measure plasma insulin levels.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01427231
|Wageningen, Gelderland, Netherlands, 6703 HD|