Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
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|ClinicalTrials.gov Identifier: NCT01427179|
Recruitment Status : Enrolling by invitation
First Posted : September 1, 2011
Last Update Posted : July 31, 2020
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.
Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.
|Condition or disease|
|Spontaneous Coronary Artery Dissection SCAD|
Study question: Do mutations within certain genes cause or confer susceptibility to spontaneous coronary artery dissection (SCAD)?
- Create a genomic DNA and plasma biobank for individuals diagnosed with SCAD.
- Identify inherited and de novo/new mutations that underlie SCAD.
- Identify common genetic variants that confer risk for SCAD.
Long term objective:Discover molecular and cellular mechanisms of SCAD and develop biomarkers to enable prediction and prevention.
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause tears in blood vessels that supply the heart. Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person. The study includes individuals diagnosed with spontaneous coronary artery dissection, their biological parents, and relatives with fibromuscular dysplasia, arterial aneurysm, or arterial dissection.
Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood or saliva sample procurement.
|Study Type :||Observational|
|Estimated Enrollment :||1000 participants|
|Official Title:||Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)|
|Study Start Date :||May 2011|
|Estimated Primary Completion Date :||December 2020|
|Estimated Study Completion Date :||December 2020|
- Identification of one or more gene mutation responsible for SCAD [ Time Frame: By end of study ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01427179
|United States, Minnesota|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Timothy M. Olson, M.D.||Mayo Clinic|
|Principal Investigator:||Sharonne N. Hayes, M.D.||Mayo Clinic|