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rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01427088
First Posted: September 1, 2011
Last Update Posted: February 18, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
HWANG TAEYOUNG, Jeonbuk Provincial Maeumsarang Hospital
  Purpose
This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.

Condition Intervention
Schizophrenia Device: CR Technology, TAMAS for repetitive TMS

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Short-Term Response of Serum Brain-Derived Neurotrophic Factor to Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Schizophrenia

Resource links provided by NLM:


Further study details as provided by HWANG TAEYOUNG, Jeonbuk Provincial Maeumsarang Hospital:

Primary Outcome Measures:
  • change from baseline of serum BDNF concentration [ Time Frame: baseline-1 week-2 week-4 week ]

Enrollment: 21
Study Start Date: August 2011
Study Completion Date: November 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: repetitive TMS
repetitive TMS is a quantified stimulation method of specifie area of brain, for which CR Technology, TAMAS for repetitive TMS was used.
Device: CR Technology, TAMAS for repetitive TMS
repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks

Detailed Description:
Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • duration of illness over 10 years
  • on stable medication, antipsychotics
  • no change on medication within at least 2 weeks
  • Diagnosis of Schizophrenia according to DSM-IV-TR

Exclusion Criteria:

  • left or both-handedness
  • anticonvulsant use
  • lorazepam equivalent over 3 mg
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01427088


Locations
Korea, Republic of
Jeonbuk Provincial Maeumsarang Hospital
Wanju, Jeonbuk, Korea, Republic of, 565844
Sponsors and Collaborators
Jeonbuk Provincial Maeumsarang Hospital
Investigators
Principal Investigator: TAEYOUNG HWANG, M.D., M.P.H. Jeonbuk Provincial Maeumsarang Hospital
  More Information

Responsible Party: HWANG TAEYOUNG, Director, Insan Research Center for Psychiatry, Jeonbuk Provincial Maeumsarang Hospital
ClinicalTrials.gov Identifier: NCT01427088     History of Changes
Other Study ID Numbers: rTMS-sBDNF-SPR-2011
First Submitted: August 28, 2011
First Posted: September 1, 2011
Last Update Posted: February 18, 2015
Last Verified: February 2015

Keywords provided by HWANG TAEYOUNG, Jeonbuk Provincial Maeumsarang Hospital:
rTMS-induced cumulative pattern of sBDNF

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders