rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia
This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Short-Term Response of Serum Brain-Derived Neurotrophic Factor to Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Schizophrenia|
- change from baseline of serum BDNF concentration [ Time Frame: baseline-1 week-2 week-4 week ] [ Designated as safety issue: No ]
|Study Start Date:||August 2011|
|Study Completion Date:||November 2011|
|Primary Completion Date:||October 2011 (Final data collection date for primary outcome measure)|
Experimental: repetitive TMS
repetitive TMS is a quantified stimulation method of specifie area of brain, for which CR Technology, TAMAS for repetitive TMS was used.
Device: CR Technology, TAMAS for repetitive TMS
repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks
Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01427088
|Korea, Republic of|
|Jeonbuk Provincial Maeumsarang Hospital|
|Wanju, Jeonbuk, Korea, Republic of, 565844|
|Principal Investigator:||TAEYOUNG HWANG, M.D., M.P.H.||Jeonbuk Provincial Maeumsarang Hospital|