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rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

This study has been completed.
Information provided by (Responsible Party):
HWANG TAEYOUNG, Jeonbuk Provincial Maeumsarang Hospital Identifier:
First received: August 28, 2011
Last updated: February 15, 2015
Last verified: February 2015
This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.

Condition Intervention
Device: CR Technology, TAMAS for repetitive TMS

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Short-Term Response of Serum Brain-Derived Neurotrophic Factor to Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Schizophrenia

Resource links provided by NLM:

Further study details as provided by Jeonbuk Provincial Maeumsarang Hospital:

Primary Outcome Measures:
  • change from baseline of serum BDNF concentration [ Time Frame: baseline-1 week-2 week-4 week ]

Enrollment: 21
Study Start Date: August 2011
Study Completion Date: November 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: repetitive TMS
repetitive TMS is a quantified stimulation method of specifie area of brain, for which CR Technology, TAMAS for repetitive TMS was used.
Device: CR Technology, TAMAS for repetitive TMS
repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks

Detailed Description:
Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.

Ages Eligible for Study:   25 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • duration of illness over 10 years
  • on stable medication, antipsychotics
  • no change on medication within at least 2 weeks
  • Diagnosis of Schizophrenia according to DSM-IV-TR

Exclusion Criteria:

  • left or both-handedness
  • anticonvulsant use
  • lorazepam equivalent over 3 mg
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Please refer to this study by its identifier: NCT01427088

Korea, Republic of
Jeonbuk Provincial Maeumsarang Hospital
Wanju, Jeonbuk, Korea, Republic of, 565844
Sponsors and Collaborators
Jeonbuk Provincial Maeumsarang Hospital
Principal Investigator: TAEYOUNG HWANG, M.D., M.P.H. Jeonbuk Provincial Maeumsarang Hospital
  More Information

Responsible Party: HWANG TAEYOUNG, Director, Insan Research Center for Psychiatry, Jeonbuk Provincial Maeumsarang Hospital Identifier: NCT01427088     History of Changes
Other Study ID Numbers: rTMS-sBDNF-SPR-2011
Study First Received: August 28, 2011
Last Updated: February 15, 2015

Keywords provided by Jeonbuk Provincial Maeumsarang Hospital:
rTMS-induced cumulative pattern of sBDNF

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders processed this record on May 23, 2017