Protein Expression in Samples From Young Patients With Rhabdomyosarcoma
RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.
Genetic: protein expression analysis
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)|
- RMS protein expression profile
Biospecimen Retention: Samples With DNA
|Study Start Date:||November 2011|
|Primary Completion Date:||May 2016 (Final data collection date for primary outcome measure)|
- To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS) tumor samples.
OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01426945
|Principal Investigator:||Corinne M. Linardic, MD, PhD||Duke Cancer Institute|