Pseudohyponatremia of Multiple Myeloma is True Hyponatremia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2011 by Meir Medical Center.
Recruitment status was  Not yet recruiting
Information provided by (Responsible Party):
Meir Medical Center Identifier:
First received: June 9, 2011
Last updated: August 28, 2011
Last verified: August 2011
Hypothesis: the hyponatremia of multiple myeloma (m.m.)is true and not pseudohyponatremia by using the stewart approach to acid - base interpretation, would like to show that the positive charged m- proteins produced in m.m.result in true hyponatremia.

Condition Intervention Phase
Hyponatremia of Multiple Myeloma
Other: blood test
Phase 4

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: a Study to Evaluate the Electrolyte Changes in Particular Sodium,in Multiple Myeloma and the Effect of the m- Proteins on the Strong Ion Difference

Resource links provided by NLM:

Further study details as provided by Meir Medical Center:

Primary Outcome Measures:
  • hyponatremia present or not [ Time Frame: one year ] [ Designated as safety issue: No ]
  • hyponatremia [ Time Frame: one year ] [ Designated as safety issue: No ]
    pseoudohyponatremia or not

Estimated Enrollment: 50
Study Start Date: September 2011
Estimated Study Completion Date: June 2012
Estimated Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
blood test
to measure levels of sodium, albumin and acid - base status in venous blood
Other: blood test
blood test to measure levels of: sodium, albumin and acid - base status in venous blood.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with gammaglobulinemia and\or multiple myeloma.

Inclusion Criteria:

  • patients with multiple myeloma
  Contacts and Locations
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Please refer to this study by its identifier: NCT01425606

Meir Hospital Not yet recruiting
Kfar Saba, Israel
Contact: jeffrey sachs, MBChB    97297471545   
Sponsors and Collaborators
Meir Medical Center
  More Information

Responsible Party: Meir Medical Center Identifier: NCT01425606     History of Changes
Other Study ID Numbers: 039-2011 
Study First Received: June 9, 2011
Last Updated: August 28, 2011
Health Authority: Israel: Ethics Commission

Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Blood Protein Disorders
Cardiovascular Diseases
Hematologic Diseases
Hemorrhagic Disorders
Hemostatic Disorders
Immune System Diseases
Immunoproliferative Disorders
Lymphoproliferative Disorders
Metabolic Diseases
Neoplasms by Histologic Type
Vascular Diseases
Water-Electrolyte Imbalance processed this record on May 26, 2016