Bioavailability of Xanthones From Mangosteen
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|ClinicalTrials.gov Identifier: NCT01425047|
Recruitment Status : Completed
First Posted : August 29, 2011
Last Update Posted : September 2, 2011
|Condition or disease|
Garcinia mangostana L. (mangosteen) is a tropical tree native to Southeast Asia. The pericarp of mangosteen fruit is used in traditional medicine to treat inflammation, infections, wounds, and diarrhea. The proposed health-promoting effects have been attributed to a family of polyphenols referred to as xanthones. Since its introduction into the United States, juices and products containing mangosteen fruit have become a top-selling botanical dietary supplement. This commercial success largely has been the result of aggressive marketing of health claims based on in vitro observations and anecdotal reports.
The purpose of this study was to determine the bioavailability of xanthones from mangosteen juice in adult human subjects. After an overnight fast of at least 10h, male and female subjects were admitted to the Ohio State University Clinical Research Center. Volunteers ingested 2 ounces of 100% mangosteen juice as part of a western-style breakfast. Pericarp particles accounted for 1% of the mass and 99% of total xanthone content in the juice. This dose provided 130 ± 2 mg total xanthones. Blood was collected prior to breakfast and 1,2,3,4,6,8 and 24h. Subjects were fed a mangosteen-free lunch and released from the unit after the 8h collection, refraining from mangosteen containing products until final collection of blood at 24h. Urine was collected for the 24 test period.
|Study Type :||Observational|
|Actual Enrollment :||10 participants|
|Official Title:||Bioavailability and Anti-inflammatory Activities of Mangostins: a Pilot Study|
|Study Start Date :||November 2010|
|Actual Primary Completion Date :||November 2010|
|Actual Study Completion Date :||February 2011|
|Females ingesting mangosteen juice|
|Males ingesting mangosteen juice|
- Xanthones in urine [ Time Frame: 0-24 hours ]Urine was collected prior to ingesting mangosteen juice with breakfast and then from consumpotion of juice until 24h.
- Xanthones in sera [ Time Frame: 0-24 hours ]Blood was collected prior to breakfast, and 1, 2, 3, 4, 6, 8 and 24 hours
Biospecimen Retention: Samples Without DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01425047
|United States, Ohio|
|The Ohio State University, Clinical Research Center|
|Columbus, Ohio, United States, 43210|
|Principal Investigator:||Mark Failla, PhD||Ohio State University|