Adjuvanted Influenza Vaccine Effectiveness in the Elderly (65+Yrs)
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ClinicalTrials.gov Identifier: NCT01424371
Recruitment Status : Unknown
Verified September 2012 by Paul VanBuynder, Fraser Health. Recruitment status was: Recruiting
This study explores the hypothesis that the use of an adjuvanted influenza vaccine in the elderly will produce greater vaccine effectiveness in their group.
Condition or disease
To evaluate the effectiveness of adjuvanted trivalent inactivated influenza vaccine in the elderly (aged ≥ 65 years) through the reduction in relative risk of microbiologically confirmed influenza illness
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Ages Eligible for Study:
65 Years and older (Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
All elderly over 65 years in the lower mainland of British Columbia presenting with an influenza-like-illness
1.Elderly tested for influenza as part of routine clinical care in the Lower Mainland and on Vancouver Island during the influenza season.
Cases: Proven influenza diagnosed on naso-pharyngeal swab via PCR Controls: Elderly with influenza-like-illness testing negative for influenza during the influenza season.
Known immunodeficiency disorders (including HIV)
Current or recent (within 90 days prior to first dose of influenza vaccine) immunosuppressive treatment including chronic oral steroids (1mg/kg for > 4 weeks), cytotoxic chemotherapy, radiation therapy, other immunosuppressive drug and biologic agents Note: Use of topical or inhalant corticosteroids is acceptable.
Administration of immunoglobulins during the study period;