Supplementation of Probiotics and Fruit Fibre to Patients With Fatty Liver
Probiotics and fruit fibre are given for 12 weeks to patients with fatty liver disease.
The hypothesis is that probiotic bacteria and fruit fibre affect the gut microbial composition in a positive manner. The improved ecological system is believed to contribute to improved liver health and thereby counteract fatty liver disease.
|Study Design:||Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Supplementation of Probiotics and Fruit Fibre to Patients With Fatty Liver|
- Improved and normalized liver status [ Time Frame: after 12 weeks intervention ] [ Designated as safety issue: No ]normalized concentrations of liver enzymes in plasma. Magnetic resonanse imaging (compared to magnetic resonanse imaging before intervention) will also be used in the investigation of improved liver status.
- Changes in the gut bacterial flora [ Time Frame: after 12 weeks intervention ] [ Designated as safety issue: No ]Changes and differences of the gut bacterial flora will be addressed in detail, e.g. changes in concentration of specific bacterial groups (e.g. Lactobacillus) before and after the intervention period.
|Study Start Date:||August 2011|
|Estimated Study Completion Date:||August 2018|
|Estimated Primary Completion Date:||August 2014 (Final data collection date for primary outcome measure)|
Experimental: Probiotics and fruit fibre
Probiotics and fruit fibre
Dietary Supplement: Probiotics and fruit fibre
probiotics and fruit fibre
Please refer to this study by its ClinicalTrials.gov identifier: NCT01423630
|Contact: Bengt Jeppsson, MD, PhDemail@example.com|
|Contact: Ingrid Palmquist||Ingrid.Palmquist@med.lu.se|
|Skåne University Hospital||Recruiting|
|Contact: Ingrid Palmquist Ingrid.Palmquist@med.lu.se|
|Contact: Bengt Jeppsson, MD, PhD firstname.lastname@example.org|