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Association Between Urine Concentration Ability and the Progression of Chronic Kidney Disease

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2011 by Meir Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by (Responsible Party):
Benaya Rozen-Zvi, Meir Medical Center Identifier:
First received: August 23, 2011
Last updated: August 24, 2011
Last verified: August 2011

The study hypothesis is that urine concentrating ability can predict the rate of kidney function decline.

Patients with kidney disease at the investigatorsclinic will be asked to give first morning urine sample and osmolarity will be measured. The investigators will follow up kidney function decline and check if there is association with urine osmolarity.

Chronic Kidney Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Association Between Urine Concentration Ability and the Progression of Chronic Kidney Disease

Resource links provided by NLM:

Further study details as provided by Meir Medical Center:

Primary Outcome Measures:
  • eGFR slope [ Time Frame: 12 month ]
    Creatinnie value will be measured at least every three month and eGFR will be calculated by MDRD equation. A regression line will be plotted against time and the eGFR slope will be calculated.

Estimated Enrollment: 200
Study Start Date: October 2011
Estimated Study Completion Date: October 2013
Estimated Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with CKD and estimated GFR of less then 50 mL per minute.

Inclusion Criteria:

  • Patients with CKD and estimated GFR of less then 50 mL per minute estimated by the short MDRD equation base on two creatinine values taken at least two weeks apart and are not getting steroids or immunosuppressive medication as treatment for their primary kidney disease.

Exclusion Criteria:

  1. Life expectancy of less then 6 month.
  2. Expected to start renal replacement therapy within 3 month.
  3. Acute or acute on chronic renal failure with reversible component.
  4. Treatment with AVP inhibitors.
  5. Chronic hyponatremia (Na+<135 in two measurement two weeks apart).
  6. Primary polydipsia.
  7. Inability to give informed consent.
  8. Clinical hypovolemia.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01423045

Pre dialysis clinic Dan Petach Tiqua county General health service Not yet recruiting
Ganey Tiqua, Israel, 55900
Contact: Benaya Rozen-zvi, MD    050-8773766   
Contact: Boris Zingerman, MD    050-6260428   
Sponsors and Collaborators
Benaya Rozen-Zvi
Principal Investigator: Benaya Rozen-Zvi, MD General health services - Dan Petach tiqua county
  More Information

Responsible Party: Benaya Rozen-Zvi, attending nephrologist pre dialysis clinic Dan petach-tiqua county, Meir Medical Center Identifier: NCT01423045     History of Changes
Other Study ID Numbers: UCONC
Study First Received: August 23, 2011
Last Updated: August 24, 2011

Keywords provided by Meir Medical Center:
Chronic kidney disease
Urine osmolarity
Glomerular filtration rate

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency processed this record on May 24, 2017