Changes of the Peripapillary Retinal Nerve Fiber Layer After Filtration Surgery in Glaucoma Patients
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|ClinicalTrials.gov Identifier: NCT01422525|
Recruitment Status : Terminated (short of study staff)
First Posted : August 24, 2011
Last Update Posted : December 2, 2014
At present, trabeculectomy is the most common performed and effective surgical method of filtration surgery for patients with medically uncontrolled glaucoma.
The aim of this prospective observational case study is to determine changes of the peripapillary retinal nerve fiber layer thickness using spectral domain optical coherence tomography in patients with glaucoma after surgical reduction of intraocular pressure.
|Condition or disease||Intervention/treatment|
|Nerve Fiber Bundle Defect Optic Nerve Diseases||Procedure: spectral domain optical coherence tomography|
Baseline and postoperative measurement of the peripapillary retinal nerve fiber layer (RNFL) thickness will be performed using the following spectral domain optical coherence tomography (OCT): Cirrus™ HD-OCT (Carl Zeiss Meditec) and Spectralis® Heidelberg-Engineering.
The main outcome measures will be changes in overall and quadrant RNFL thickness with respect to reduction in intraocular pressure (IOP), correlation between RNFL thickness and alteration in visual field and predictive factors of postoperative IOP-reduction and changes of RNFL thickness.
|Study Type :||Observational|
|Actual Enrollment :||12 participants|
|Official Title:||Effect of Trabeculectomy on Peripapillary Retinal Nerve Fiber Layer Thickness Using Spectral Domain Optical Coherence Tomography|
|Study Start Date :||November 2011|
|Actual Primary Completion Date :||February 2012|
|Trabeculectomy RNFL thickness OCT||
Procedure: spectral domain optical coherence tomography
RNFL thickness measurement using spectral domain optical coherence tomography at baseline, 1, 3 and 6 months postoperatively.
- change of retinal nerve fiber layer thickness [ Time Frame: 6 months ]study was terminated
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01422525
|University Eye Hospital Wuerzburg|
|Wuerzburg, Bavaria, Germany, 97080|