Biomarkers in Samples From Adult Patients With Acute Myeloid Leukemia Who Failed Existing Standard-of-Care Treatment
|ClinicalTrials.gov Identifier: NCT01421862|
Recruitment Status : Unknown
Verified August 2011 by National Cancer Institute (NCI).
Recruitment status was: Not yet recruiting
First Posted : August 23, 2011
Last Update Posted : July 10, 2013
RATIONALE: Studying samples of bone marrow and blood from patients with cancer who failed treatment may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer resistance. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies biomarkers in samples from adult patients with acute myeloid leukemia who failed standard-of-care treatment.
|Condition or disease||Intervention/treatment|
|Leukemia||Genetic: DNA methylation analysis Genetic: RNA analysis Genetic: gene expression analysis Genetic: microarray analysis Genetic: mutation analysis Genetic: nucleic acid sequencing Other: laboratory biomarker analysis|
- Define a "non-response" signature that will help up-front identification of cases of intermediate-risk acute myeloid leukemia (AML) destined to fail existing standard-of-care therapy.
- Identify biological pathways in the "non-response" group that can provide targets for novel therapeutics.
OUTLINE: DNA and RNA extracted from cryopreserved bone marrow cells and/or blood cells are analyzed for mutations and gene expression signatures (genome-wide methylation, mRNA and miRNA expression, and single nucleotide polymorphism (SNP) analysis) by microarray assays.
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Official Title:||The Genetics of "Non-Response" in Adult AML|
|Study Start Date :||September 2011|
|Estimated Primary Completion Date :||October 2011|
- Genetic signature predictive of progression and drug resistance in AML
- Identification of biological pathways in non-responder AML patients
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01421862
|Principal Investigator:||Jerry Radich, MD||Fred Hutchinson Cancer Research Center|